Sökning: "CIN"

Visar resultat 11 - 15 av 46 avhandlingar innehållade ordet CIN.

1. 11. Immunological responses in genital HPV infections and etiology of cervical cancer

   Författare :Lisen Arnheim; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HPV; CIN; cervical cancer; antibodies; KIRs; CXCL8; IFN-gamma; Chlamydia trachomatis;

   Sammanfattning : Cervical cancer is one of the most common forms of cancers in women. Every year approximately 450,000 women are diagnosed worldwide and 200,000 die. The sexually transmitted oncogenic human papillomavirus (HPV) types are established as the major etiological agents of cancer of the cervix. LÄS MER

3. 12. Cervical cancer screening. Knowledge, attitudes and experiences among women and midwives

   Författare :Monica Ideström; Göteborgs universitet; []
   Nyckelord :cervical cancer screening; cervical cancer; Papanicolaou smear; knowledge; attitude; ; experience; coping; dysplasia; cervical intraepithelial neoplasia CIN ; midwife; information; Grounded Theory;

   Sammanfattning : Population based cervical cancer screening (CCS), performed by midwives, to detect cellularatypia before it develops into cancer, has been in force in Sweden since the 1970s. Thepositive effects of the subsequent decline in morbidity and mortality due to cervix cancer arewell documented but does screening also have negative consequences?Aims: To investigate knowledge about, attitudes to and experience of CCS (i) among womenin general, (ii) among women with experience of two mildly atypical Pap smears, (iii) amongwomen diagnosed with cervical cancer and (iv) among midwives who manage CCS. LÄS MER

4. 13. Immunogenetic markers in immune mediated diseases

   Författare :Liene Nikitina-Zake; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HLA; MICA; TNFA; TNFa; KIR; CIN; cervical cancer; juvenile arthritis; MCTD; type I diabetes mellitus;

   Sammanfattning : The aim of this thesis was to study HLA class II markers, as well as other - MHC and non MHC genes in different immune - mediated diseases, namely, cervical intraepithelial neoplasia (CIN), cervical cancer, juvenile idiopathic arthritis (JIA), mixed connective tissue disease (MCTD) and type I diabetes mellitus (T1 DM). HLA class II genes are located on the short arm of chromosome 6 and are known to be important for pathogenesis of immune-mediated diseases due to the function of the molecules these genes encode. LÄS MER

5. 14. Type-specific human papillomavirus antibodies : detection, characterization and application in seroepidemiology

   Författare :Zhaohui Wang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :antagonism; antibody; capsids; cervical carcinoma; CIN; epidemiology; HPV; isotype; neutralizing epitope; PCR; STDs; trends over time; VLPs;

   Sammanfattning : Background: Human Papillomavirus (HPV) is a sexually transmitted DNA virus that causes several human cancers, notably cervical and other anogenital cancers. The antibody response to this virus is of interest both because knowledge of the antigenic structures that induce protective immunity forms the basis for prophylactic vaccine development and because it forms the basis of seroepidemiology, the method of choice for studies of HPV infectivity, of HPV spread in populations and of cancer risks following HPV exposure. LÄS MER

7. 15. Human papillomaviruses : role in cervical dysplasia and carcinoma, and use as molecular risk marker for progression

   Författare :Mina Kalantari; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Human papillomavirus; high risk; HPV; PCR; typing; cervical carcinoma; CIN; integration; disruption; deletion; El; E2; survival; inverse PCR; episomal DNA; FISH; chromosomal location;

   Sammanfattning : The general aim of these studies was to define the role of infection with oncogenic human papillomaviruses (HPV) for development of cervical dysplasia and to obtain early molecular markers for progression to carcinoma. The results of cytological screening of 500 women in the Stockholm Gynaecologic Health Control were compared with HPV detection by polymerase chain reaction (PCR) and in situ hybridisation (ISH). LÄS MER