Sökning: "capsids"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet capsids.

  1. 1. Control of Quasi-Equivalence in Virus Capsids

    Författare :Charlotte Helgstrand; B. V. Venkataram Prasad; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; crystallography; bacteriophage; virus; RNA; capsid; quasi-equivalence; assembly; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Many T=3 plant and insect viruses use a molecular switch in form of order/disorder of a segment of the polypeptide chain to regulate the quasi-equivalent contacts. The structure of a mutant of the T=3 capsid of bacteriophage fr confirms that this virus and other members of the Leviviridae family lack a switch mechanism. LÄS MER

  3. 2. Protein adaptability involved in self-assembled icosahedral capsids

    Författare :Josefina Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :BK virus; lumazine synthase; virus-like particle; electron cryomicroscopy; quasiequivalence; assembly;

    Sammanfattning : Interactions between viral coat proteins determine the size and shape of the virus capsid. Therefore, the plain closed shell of a spherical virus provides an excellent resource for studying and testing protein-protein interactions so as to reveal the properties that lead to symmetrical capsids or other shapes. LÄS MER

  4. 3. Structural Decorations in Viruses : Unraveling Acquired Functional Structures in Icosahedral RNA Virus Capsids

    Författare :Han Wang; Kenta Okamoto; Sarah Butcher; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Viruses; RNA viruses; capsid; structure; cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Viruses have a profound impact worldwide, posing challenges to animal welfare, agriculture, human health, and the ecosystem. This thesis examines the realm of non-enveloped icosahedral double-stranded (ds)RNA and single-stranded (ss)RNA viruses through three studies. LÄS MER

  5. 4. The Design and Structure Prediction of Protein Oligomers

    Författare :Robert Lizatovic; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virus capsids; coiled coils; molecular replacement; symmetry; Rosetta; protein design; structure prediction;

    Sammanfattning : The minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. LÄS MER

  7. 5. Type-specific human papillomavirus antibodies : detection, characterization and application in seroepidemiology

    Författare :Zhaohui Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :antagonism; antibody; capsids; cervical carcinoma; CIN; epidemiology; HPV; isotype; neutralizing epitope; PCR; STDs; trends over time; VLPs;

    Sammanfattning : Background: Human Papillomavirus (HPV) is a sexually transmitted DNA virus that causes several human cancers, notably cervical and other anogenital cancers. The antibody response to this virus is of interest both because knowledge of the antigenic structures that induce protective immunity forms the basis for prophylactic vaccine development and because it forms the basis of seroepidemiology, the method of choice for studies of HPV infectivity, of HPV spread in populations and of cancer risks following HPV exposure. LÄS MER