Sökning: "5´-untranslated region"

Visar resultat 6 - 10 av 23 avhandlingar innehållade orden 5´-untranslated region.

1. 6. The Role of RNA Binding Proteins in Insulin Messenger Stability and Translation

   Författare :Rikard G. Fred; Nils Welsh; Michele Solimena; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Although the reason for insufficient release of insulin in diabetes mellitus may vary depending on the type and stage of the disease, it is of vital importance that an amplified insulin biosynthesis can meet the increased need during periods of hyperglycemia. The insulin mRNA is highly abundant in beta cells and changes in insulin mRNA levels are, at least in part, controlled by altered rates of mRNA degradation. LÄS MER

3. 7. FOXC2 and CAPN10 as candidate genes for obesity, insulin resistance and type 2 diabetes

   Författare :Emma A Nilsson; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicinska vetenskaper; Biomedical sciences; Type 2 diabetes; Genetics; Obesity;

   Sammanfattning : The worldwide prevalence of obesity and type 2 diabetes is increasing rapidly. Both disorders depend on genetic and environmental factors. The studies included in this thesis investigated the possible association of the FOXC2 and CAPN10 genes with obesity, insulin resistance, type 2 diabetes, and related phenotypes. LÄS MER

4. 8. Untangling the contribution of untranslated regions to mRNA translation in health and disease

   Författare :Johannes Ristau; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Protein homeostasis is essential for living organisms and a consequence of steps of the gene expression pathway such as transcription, mRNA translation as well as the degradation of mRNA and proteins. These major cellular events demand tight control, high maintenance, and require a large proportion of cellular resources. LÄS MER

5. 9. Role of the CDKN2A and related cell cycle regulatory genes in melanoma and other human cancers

   Författare :Johanna Smeds; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CDKN2A; ARF; p53; cell cycle regulation; mutation; melanoma; esophageal squamous cell carcinoma;

   Sammanfattning : The main objective of this thesis has been to investigate the involvement of the CDKN2A (p16INK4a and p14ARF) and related cell cycle regulatory genes in melanoma and other types of human cancer. The CDKN2A gene represents a unique locus in the entire human genome. LÄS MER

7. 10. Characterization of non-coding mRNA in Epstein-Barr virus

   Författare :Åsa Isaksson; Göteborgs universitet; []
   Nyckelord :Epstein-Barr virus; EBNA1; IRES; PTLD; alternative splice; nucleotide substitution; protein interactions;

   Sammanfattning : Epstein-Barr virus (EBV) is a human gammaherpesvirus that infects lymphoid and epithelial cells. The virus is the causative agent of infectious mononucleosis, a self-limiting lymphoproliferative disease, and it is additionally associated with various malignancies including Burkitt?s lymphoma, Hodgkin?s disease and lymphoproliferative syndromes in immunocompromised individuals. LÄS MER