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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Endometrial carcinoma : prognostic factors and protein expression profiling

    Författare :Caroline Lundgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endometrial carcinoma; prognosis; DNA ploidy; MIB-1; p53; laminin-5 72 chain; 2DE;

    Sammanfattning : Endometrial carcinoma is the most common gynaecological cancer in the western world. It is usually diagnosed at an early stage since it presents with irregular vaginal bleeding when the tumour is still limited to the uterus and the prognosis is generally favourable. LÄS MER

  2. 2. In search of diagnostic and prognostic markers for thyroid cancer : a proteomics approach

    Författare :Anastasios Sofiadis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thyroid tumors; thyroid proteomics; S100A6; MIB-1; 2DE; MALDI-TOF-MS; SELDI-TOF-MS; protein pre-fractionation;

    Sammanfattning : Early diagnosis of cancer can influence the therapeutic strategy increasing the chances of cure or, at least, prolonged survival. It is equally important to be able to detect prognostic signs, i.e. tumor features that characterize its behavior. LÄS MER

  3. 3. Left ventricular remodeling and function in ischemic heart disease and aortic valve disease

    Författare :Jonas Jenner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Cardiac remodeling is a broad term that refers to structural and functional alterations of the heart in response to chronic changes in loading conditions or left ventricular (LV) contractile performance. Different loading conditions will affect the heart in different ways, some leading to impaired heart function, symptoms of heart failure, or even death. LÄS MER

  4. 4. Quantitative proteomic approaches for the analysis of human lung samples in pulmonary sarcoidosis

    Författare :Ernesto Silva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis is focused on the analysis of protein expression profiles from the airways of sarcoidosis patients using quantitative proteomics. Sarcoidosis is a multisystemic inflammatory disorder of unknown etiology characterized by the presence of noncaseating granulomas in the affected organs. LÄS MER

  5. 5. Profiling the cancer proteome

    Författare :Sofia Waldemarson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cytologi; onkologi; cancer; Biotechnology; Bioteknik; cancerology; oncology; Cytology; iTRAQ; biomarkers; DIGE; two-dimensional gel electrophoresis; Proteomics;

    Sammanfattning : Cancer is a complex and heterogeneous disease where cells have started to grow uncontrolled and this disease remains a major health problem. Because of diffuse symptoms it often presents at a late stage. LÄS MER