Sökning: "[alpha]2-adrenergic receptors"

Hittade 4 avhandlingar innehållade orden [alpha]2-adrenergic receptors.

  1. 1. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

    Författare :Johnny Näsman; Peter Evans; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Sammanfattning : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. LÄS MER

  3. 2. Experimental Injury to the Visual System : Molecular Studies of the Retina

    Författare :Ulrika Lönngren; Finn Hallböök; Fredrik Ghosh; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retina; injury; ischemia; gene expression; brimonidine; alpha-2-adrenergic agonist; neuroprotection; growth factors; apoptosis; Müller cells; Neuroscience; Neurovetenskap;

    Sammanfattning : Retinal ganglion cells play a crucial role in the relay of visual signals from the eye to the brain. This cell type is affected and eventually lost in the eye disease glaucoma, resulting in progressive and irreversible loss of vision. LÄS MER

  4. 3. Islet glucose metabolism and insulin release in two animal models of glucose intolerance

    Författare :Zong-Chao Ling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Goto-Kakizaki GK rat; transgenic mice; glucose-6-phosphatase activity; insulin secretion; glucocorticoids; [alpha]2-adrenergic receptors; hyperglycemia;

    Sammanfattning : Type 2 diabetes is a complex and heterogenous disease resulting from the interaction of defects of both genetic and environmental origin. Abnormalities contributing to the pathogenesis of type 2 diabetes include impaired [beta]-cell function, peripheral insulin resistance and increased hepatic glucose production. LÄS MER

  5. 4. Impact of candidate genes on obesity and type 2 diabetes

    Författare :Ewa-Carin Långberg; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Obesity and type 2 diabetes (T2D) have strong genetic components. Identification of susceptibility genes in both diseases will give better knowledge of their pathomechanisms and future therapies. LÄS MER