Sökning: "tumor vaccine"

Visar resultat 11 - 15 av 44 avhandlingar innehållade orden tumor vaccine.

1. 11. Tumor-mediated changes in the immune system of cancer patients : a balancing act between suppressors and effectors

   Författare :Isabel Poschke; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Tumors and immune cells interact in many ways: immune cells can recognize and even kill tumor cells, while the tumor on the other hand can induce cells of the immune system to participate in tumor-mediated immune subversion. We studied immunosuppressive effects that human tumors exert on immune effector cells, particularly T cells, by inducing suppressive myeloid cells and decreasing T cell functional capacity. LÄS MER

3. 12. Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia

   Författare :Parviz Kokhaei; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Immunotherapy; dendritic cells. chronic lymphocytic leukemia; tumor vaccine; T lymphocyte;

   Sammanfattning : A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for loading antigen on dendritic cells (DC) with the aim of delineating the most effective antigen presentation platform for stimulating anti-leukemic T cells. LÄS MER

4. 13. Delivery of DNA vaccines against cancer

   Författare :Anna-Karin Roos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA vaccine; prostate-specific antigen; immunotherapy; prostate cancer; electroporation;

   Sammanfattning : DNA vaccines against cancer have shown promising results in animal models. Efficient antigenspecific T cell responses and tumor protection have been demonstrated after vaccination with DNA encoding tumor antigens in mice. LÄS MER

5. 14. Induction of t-cell responses against PSA by plasmid DNA immunization

   Författare :Maxim Pavlenko; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Prostate-specific antigen; DNA vaccine; cytotoxic T lymphocytes;

   Sammanfattning : This thesis is focused on using plasmid DNA encoding human prostate-specific antigen (PSA) for immunotherapy of prostate cancer. PSA is a secreted serine protease, which is produced almost exclusively by prostate epithelial cells. LÄS MER

7. 15. Hantaviruses : animal models, immunology and pathogenesis

   Författare :Jonas Klingström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Hantavirus; animal models; vaccine; passive immunization; nitric oxide;

   Sammanfattning : Hantaviruses cause two serious and often fatal human zoonotic diseases: hemorrhagic fever with renal syndrome (HFRS) in Eurasia, and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Hantaviruses are rodent-borne and are transmitted to humans via inhalation of contaminated rodent excreta. LÄS MER