Sökning: "tumor necrosis factor"

Visar resultat 26 - 30 av 217 avhandlingar innehållade orden tumor necrosis factor.

  1. 26. Regulation of prostaglandin E2 synthesis in human gingival fibroblasts

    Författare :Tülay Yucel-Lindberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostaglandin E2; cyclooxygenase; phospholipase A2 interleukin-1; tumor necrosis factor [alpha]; epidermal growth factor; protein kinase C; tyrosine kinases; human gingival fibroblasts;

    Sammanfattning : Prostaglandins, especially, prostaglandin E2 (PGE2) play an important role in inflammatory diseases such as rheumatoid arthritis and periodontitis. The aim of the present thesis was to study the production and the regulation of PGE2 with special reference to the key enzymes phospholipase A2 (PLA2) and cyclooxygenase (COX) at the rnRNA level in human gingival fibroblasts. LÄS MER

  3. 27. Effects of lipid oxidation on transcriptional regulation and cell death

    Författare :Mikko Ares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; low density lipoprotein; lipid oxidation; nuclear factor-KB; activator protein-1; Iysophosphatidylcholine; tumor necrosis factor-alpha; oxysterol; Ca2 ; apoptosis; lipid accumulation;

    Sammanfattning : Elevated levels of low density lipoprotein (LDL) in plasma are associated with an increased risk for atherosclerosis. Excessive accumulation of lipoproteins and lipids in the vascular wall is thought to lead to the development of advanced atherosclerotic lesions prone to rupture. LÄS MER

  4. 28. Modulation of the inflammatory response in experimental bacterial meningitis

    Författare :Carl Granert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bacteria; meningitis; adhesion; leukocytes; microcirculation; fucoidin; cytokines; tumor necrosis factor; interleukin; CNI-1493; macrophage; CNS; inflammation; experimental;

    Sammanfattning : In bacterial meningitis, tissue damage in the central nervous system (CNS) is inflicted by the host's inflammatory response to invading pathogens, rather than by the bacteria itself. Adjuvant treatment with anti-inflammatory drugs in experimental bacterial meningitis has demonstrated beneficial effects on CNS pathology. LÄS MER

  5. 29. Pain and radiographic changes of the arthritic temporomandibular joint : relation to cytokines in synovial fluid and plasma

    Författare :Silvi Nordahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arthritis; Bone loss; Interleukin- 1 beta; Pain; Plasma; Progression; Radiographic changes; Synovial fluid; Temporomandibular joint; Tumor Necrosis Factor alpha;

    Sammanfattning : In patients with rheumatoid arthritis and other inflammatory joint diseases, radiographic changes of the TMJ are frequently observed. Common symptoms of TMJ involvement are pain at rest and on movement of the jaw. LÄS MER

  7. 30. Studies on mechanisms in liver fibrosis

    Författare :Nils Kinnman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :bile duct epithelial cell; chernotaxis; cholestasis; cystic fibrosis; cystic fibrosis transmembrane conductance regulator; endothelin; hepatic stellate cell; hepatitis C virus; liver fibrosis; platelet-derived growth factor; platelet-derived growth factor receptor [beta]; smooth muscle [alpha]-actin; transforming growth factor- [beta]; tumor necrosis factor-[alpha];

    Sammanfattning : The aim of the present study was to elucidate mechanisms involved in liver fibrogenesis, the wound healing response of the liver to chronic injury. A role for TNF-[alpha] and all three isoforms of TGF-[beta] in the pathogenesis of hepatitis C related liver disease was suggested by the finding of increased expression of TGF-[beta]1-3, latent TGF-[beta] binding protein (LTBP), and TNF-[alpha] by immunohistochemistry in areas of inflammation and fibrosis in liver tissue from untreated patients with hepatitis C. LÄS MER