Sökning: "Interleukin- 1 beta"

Visar resultat 1 - 5 av 42 avhandlingar innehållade orden Interleukin- 1 beta.

  1. 1. Effects of Interleukin-4 and Interleukin-13 on Bone

    Författare :Carl-Johan Silfverswärd; Olle Nilsson; Östen Ljunggren; Kenneth Jonsson; Li Felländer-Tsai; Uppsala universitet; []
    Nyckelord :Medicine; Bone; Osteoblasts; Interleukin-4; Interleukin-13; Knockout; Medicin;

    Sammanfattning : Cytokines play important roles in bone metabolism, participating in the complex interplay necessary for normal bone formation and turnover. The aim of the present thesis was to investigate the effects of two anti-inflammatory cytokines, interleukin-4 (IL-4) and interleukin-13 (IL-13) on bone. LÄS MER

  2. 2. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

    Författare :Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

    Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

  3. 3. Immunological effects of interferon-beta and glatiramer acetate in multiple sclerosis

    Författare :Yassir Hussien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Multiple sclerosis; Interferon-beta; Glatiramer acetate; Dendritic cells; Mononucealar cells;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in demyelination, axonal loss and neurological deficits. The aetiology is unknown, however, immunopathological events, which are believed to be of an autoimmune nature, are considered to be responsible for the development of the disease. LÄS MER

  4. 4. Mechanisms of defective insulin secretion in type 2 diabetes

    Författare :Taman Mahdi; Diabetes - öpatofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; Insulin secretion; TCF7L2; ADRA2A; KCNQ1; SFRP4; interleukin-1B;

    Sammanfattning : Defective insulin secretion from the pancreatic B-cells is a central feature in type 2 diabetes (T2D). There is a strong hereditary component in type T2D, but the underlying pathophysiology remains largely unknown. LÄS MER

  5. 5. Activation of murine cytotoxic cells with interelukin-2 and the bacterial superantigen staphylococcal entertoxin A

    Författare :Hans Belfrage; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; cytokine; tolerance; LAK; NK; serologi; CTL; Staphylococcal enterotoxin A; SEA; Interleukin-2; murine; deletion; anergy;

    Sammanfattning : Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. LÄS MER