Sökning: "transcript characterization"

Visar resultat 11 - 15 av 33 avhandlingar innehållade orden transcript characterization.

1. 11. Genetic and biological characterization of the anorexic anx/anx mouse

   Författare :Jeanette Johansen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Pathological deviations in body weight is a major health problem. It is currently unclear how normal body weight and food intake is controlled. There is even less understanding of the mechanisms behind abnormal eating behavior as in anorexia and obesity. LÄS MER

3. 12. Cloning and characterization of a p-53-inducible gene, WIG-1

   Författare :Shohreh Varmeh-Ziaie; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Elucidating the mechanisms by which p53 inhibits tumor growth is a central issue in cancer research, as the TP53 gene is mutated in over half of all human cancers. Lack of functional p53 also contributes to the resistance of many tumor types to chemotherapy and radiotherapy. LÄS MER

4. 13. Characterization of Genetic Abnormalities at Disease Progression of Chronic Myeloid Leukemia

   Författare :Aikaterini Barbouti; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fluorescent in situ hybridization; low-copy repeats; isochromosome 17q; MSI2 HOXA9; ETV6 ABL1; BCR ABL1; chronic myeloid leukemia; blast crisis; molecular genetics; Clinical genetics; Klinisk genetik;

   Sammanfattning : Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the translocation t(9;22)(q34;q11) and progresses from a relatively indolent chronic phase (CP) to an accelerated phase (AP) and finally to the more aggressive blast crisis (BC). The general aim of this thesis was to identify and characterize genetic abnormalities occurring at disease progression of CML using molecular cytogenetic, molecular genetic, and bioinformatic analyses. LÄS MER

5. 14. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

   Författare :Sanaz Gabery; Translationell neuroendokrinologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; oxytocin; vasopressin; orexin; CART; neuroendocrinology; MRI; 3 Tesla; volymetric analysis;

   Sammanfattning : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. LÄS MER

7. 15. Isolation and functional characterization of Hrp65-binding proteins in Chironomus tentans

   Författare :Eva Kiesler; Neus Visa; Benjamin Blencowe; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gene expression; RNA-binding proteins; mRNA biogenesis; nuclear structure; Molecular biology; Molekylärbiologi;

   Sammanfattning : It is well-established that the organization of nuclear components influences gene expression processes, yet little is known about the mechanisms that contribute to the spatial co-ordination of nuclear activities. The salivary gland cells of Chironomus tentans provide a suitable model system for studying gene expression in situ, as they allow for direct visualization of the synthesis, processing and export of a specific protein-coding transcript, the Balbiani ring (BR) pre-mRNA, in a nuclear environment in which chromatin and non-chromatin structures can easily be distinguished. LÄS MER