Sökning: "therapeutic targets"

Visar resultat 31 - 35 av 415 avhandlingar innehållade orden therapeutic targets.

  1. 31. Astrocytes in glioblastoma : enhancers of tumor growth, predictors of patient survival and potential therapeutic targets

    Författare :Alessandro Mega; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The tumor microenvironment plays an important role in glioblastoma, the most malignant primary brain tumor in adults. Astrocytes are a major component of the glioblastoma tumor microenvironment; therefore, their influence on glioblastoma biology needs to be clarified. LÄS MER

  3. 32. Investigating histidine-rich glycoprotein and T cell-specific adaptor as potential biomarkers and therapeutic targets

    Författare :Tor Persson Skare; Lena Claesson-Welsh; Mats Hellström; Elin Sjöberg; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Histidine-rich glycoprotein; T cell-specifik adaptor; Lymphoma; Glioblastoma; Vascular permeability;

    Sammanfattning : The endothelial cell (EC), the most important cell type in blood vessels, lines the vessel wall and provides vessel integrity. EC function is tightly regulated, and its dysregulation is a key element in many diseases including cardiovascular disease, cancer and several diseases of the eye. LÄS MER

  4. 33. Biological and therapeutic aspects of breast cancer progression

    Författare :Karthik Govindasamy Muralidharan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer is the second leading cause of cancer related death in women worldwide1. Although majority of primary breast cancers are curable with current treatment strategies, treatment outcome of metastatic breast cancer is dismal. LÄS MER

  5. 34. Development of therapeutic strategies for quiescent tumor cell populations

    Författare :Xiaonan Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Phenotypic screening is an effective approach to the discovery of small-molecule drugs. In this thesis, I have used cancer cells grown as 3D microtissues (multicellular spheroids) to study the effect of anticancer drugs and as drug discovery tools. LÄS MER

  7. 35. Molecular and therapeutic aspects of breast cancer stem cells

    Författare :Ran Ma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Breast cancer stem cells (BCSCs) are defined as a minor cellular component in the solid tumor, displaying mammary stem cell properties by expressing embryonic stem cell genes. They are usually undergoing self-. LÄS MER