Sökning: "therapeutic targets"

Visar resultat 16 - 20 av 414 avhandlingar innehållade orden therapeutic targets.

  1. 16. Chemoattractants as causative agents, biomarkers and therapeutic targets in vascular pathology

    Författare :Yuri Sheikine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; coronary artery disease; restenosis; chemokines; eicosanoids;

    Sammanfattning : Atherosclerosis and restenosis are driven by chronic immune response in the vascular wall. This involves cell migration into and within the vessel wall, cell proliferation as well as accumulation of lipids in the vessel wall. These processes are mediated, among other substances, by molecules belonging to a large family of chemoattractants. LÄS MER

  3. 17. Microglia : health promoting pathways and therapeutic targets in ageing and neuroinflammation

    Författare :Rasmus Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microglia are the innate immune cells of the CNS with an embryonic origin and self-renew with a slow turnover throughout life. The health-promoting capacities of this cell are being acknowledged through updated and specific tools separating microglia from bone marrow-derived macrophages. LÄS MER

  4. 18. Tumor instructed normal tissue : studies of potential extratumoral biomarkers and therapeutic targets in prostate cancer

    Författare :Maria Nilsson; Sofia Halin Bergström; Anders Bergh; Kristian Pietras; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; biomarkers; tumor-instructed normal tissue; extra cellular matrix; macrophages; LOX; HO-1; MSMB; Pathology; patologi;

    Sammanfattning : Prostate cancer is the most common cancer in men in Sweden and but luckily the majority of the patients will carry on their life without any consequences from the disease. Unfortunately, some will develop aggressive tumors and eventually die. LÄS MER

  5. 19. Assessment of therapeutic targets in experimental models of Myc-induced lymphoma

    Författare :Linus Plym Forshell; Jonas Nilsson; Lars-Gunnar Larsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Myc; Decitabine; Pim kinase; RCAS-tva; Neurobiology; Neurobiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The Myc transcription factor activates expression of genes that promote cellular functions such as proliferation and cell growth. The deregulated Myc expression, characteristic for the tumor cell, also activates apoptosis, which selects for additional genetic changes deactivating the induced cell death. LÄS MER

  7. 20. Identifying molecular targets for cancer therapy

    Författare :W David Culp; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Within cancer research a molecular target is a specific molecular attribute in a cancer cell or tumor tissue that may play a role in promoting disease progression. There are many of these molecular attributes present in cancer biology and they represent events for therapeutic intervention. LÄS MER