Sökning: "telomere length"
Visar resultat 21 - 25 av 46 avhandlingar innehållade orden telomere length.
21. A short story of the long telomere : evidence in aging epidemiology
Sammanfattning : Telomeres are the sequences of nucleotides at the end of chromosomes. Each time a cell divides, telomeres become shorter. The length of telomeres can be replenished by an enzyme, telomerase. Telomere shortening is hypothesized as the biological origin of aging. LÄS MER
22. Cellular consequences of preterm birth : telomere biology, immune development and oxidative stress
Sammanfattning : Preterm infants are at risk for oxidative stress just by being born. The extra-uterine environment is relatively oxygen-rich, their antioxidant defenses are immature, diseases and treatments in the neonatal period will trigger inflammatory responses. LÄS MER
23. The role of telomerase reverse transcriptase (TERT) in human malignancies : genetic regulation and telomere lengthening-independent oncogenic activities
Sammanfattning : Telomerase is a ribonucleoprotein enzyme maintaining telomere length. Telomerase reverse transcriptase (TERT), which acts as a catalytic unit, is tightly repressed in differentiated human cells while activated in cancer cells for telomere lengthening. LÄS MER
24. Towards ribozyme-mediated gene therapy of HIV-1 infections
Sammanfattning : HIV-1 is the causative agent in AIDS, the world's fourth most frequent cause of death. HIV is a retrovirus that primarily infects macrophages and T helper cells - required for a proper immune response. LÄS MER
25. Molecular ecology of marine mammals
Sammanfattning : Marine mammals comprise a paraphyletic group of species whose current abundance and distribution has been greatly shaped by past environmental changes and anthropogenic impacts. This thesis describes molecular ecological approaches to answer questions regarding habitat requirements, genetic differentiation, and life-history trade-offs in three species of marine mammals. LÄS MER