Sökning: "telomere length"

Visar resultat 11 - 15 av 46 avhandlingar innehållade orden telomere length.

  1. 11. Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain

    Författare :Mikael Wikgren; Karl-Fredrik Norrback; Rolf Adolfsson; Göran Roos; Thomas Karlsson; Brenda Penninx; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APOE; aging; atrophy; brain; cognition; cortisol; depression; hippocampus; HPA axis; MRI; stress; telomere length; white matter hyper-intensities.;

    Sammanfattning : Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. LÄS MER

  3. 12. Studies of molecular mechanisms of telomere maintenance in Naumovozyma castellii

    Författare :Ahu Karademir Andersson; Molekylär cellbiologi; []
    Nyckelord :YEAST; Saccharomyces castellii; Naumovozyma castellii; Processvity; Telomerase; Telomere; ALT; Strain engineering;

    Sammanfattning : Telomeres are special DNA-protein structures that protect ends of chromosomes from being recognized as double-strand breaks. Telomeres consist of tandemly repeated units of TG-rich DNA and associate with telomere-specific proteins. LÄS MER

  4. 13. Novel mechanisms in depression: focus on telomere biology and epigenetic regulation

    Författare :Yabin Wei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Telomere length;

    Sammanfattning : Depression is a complex disorder with an average lifetime prevalence from 11.1% to 14.6%. It causes serious disability and is a significant public health problem worldwide. LÄS MER

  5. 14. Fine and ultrafine particle exposure: Health effects and biomarkers

    Författare :Yiyi Xu; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :particulate matter; Occupational Exposure : adverse effects; mitochondrial dna; telomere length;

    Sammanfattning : Particle, especially fine and ultrafine particle exposure has been linked to lower airway infections, asthma, chronic obstructive pulmonary disease (COPD), ischemic heart disease, stroke and cancer. The underlying mechanisms are under active investigation, and are still not fully understood. LÄS MER

  7. 15. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

    Författare :Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. LÄS MER