Sökning: "telomere length"

Visar resultat 6 - 10 av 46 avhandlingar innehållade orden telomere length.

1. 6. Telomere length as prognostic parameter in chronic lymphocytic leukemia

   Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

   Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER

3. 7. Functional Studies of Telomere-Binding Proteins in Saccharomyces castellii

   Författare :Jenny Rhodin; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Rap1; DNA-binding domain; telomere evolution; Cdc13; telomerase; single-stranded overhang; telomere; yeast; Naumovia castellii; Saccharomyces castellii;

   Sammanfattning : Telomeres are the ends of linear eukaryotic chromosomes. The telomeres are essential for solving the end replication problem and they stabilize the genome by protection from degradation. The telomeres also protect the chromosomal ends from by being recognized as DNA breaks by the repair machinery, which could lead to end-to-end fusions. LÄS MER

4. 8. RAP1 at the Yeast Telomere

   Författare :Johan Wahlin; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytogenetik; DNA-binding; Saccharomyces; yeast; telomeric repeat; telomere; RAP1; repressor activator protein 1; Genetics; cytogenetics; Genetik;

   Sammanfattning : Telomeres are specialized complexes of DNA and proteins that cap and confer stability to the ends of eukaryotic chromosomes. The telomeric DNA of most eukaryotes is composed of tandemly arranged short repeats. Within the budding yeasts these repeats are diverged in length as well as in nucleotide composition. LÄS MER

5. 9. The immortalization process of T cells : with focus on the regulation of telomere length and telomerase activity

   Författare :Sofie Degerman; Göran Roos; John Sedivy; Umeå universitet; []
   Nyckelord :immortalization; senescence; T cells; Nijmegen breakage syndrome; telomere; telomerase; hTERT; generic aberrations; methylation; MEDICINE; MEDICIN; Pathology; patologi;

   Sammanfattning : Cellular immortalization is a major hallmark of cancer and is a multi-step process that requires numerous cell-type specific changes, including inactivation of control mechanisms and stabilization of telomere length. The telomeres at the chromosome ends are essential for genomic stability, and limit the growth potential of most cells. LÄS MER

7. 10. Telomere analysis of normal and neoplastic hematopoietic cells : studies focusing on fluorescence in situ hybridization and flow cytometry

   Författare :Magnus Hultdin; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; telomere; telomerase; fluorescence in situ hybridization; flow cytometry; flow-FISH; replication timing; chronic lymphocytic leukemia; immunoglobulin gene; prognosis; Biomedicin; Microbiology; Mikrobiologi; Medical Cell Biology; medicinsk cellbiologi;

   Sammanfattning : The telomeres are specialized structures at the end of the chromosomes composed of the repeated DNA sequence (TTAGGG)n and specific proteins bound to the DNA. The telomeres protect the chromosomes from degradation and end to end fusions. LÄS MER