Sökning: "sustained release"

Visar resultat 21 - 25 av 85 avhandlingar innehållade orden sustained release.

  1. 21. Design of new biodegradable polymer matrices for controlled drug delivery

    Författare :Ulrica Edlund; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymer chemistry; Polymerkemi;

    Sammanfattning : Conventional drug administration technologies display poorcontrollability, and lead to high plasma concentrations andshort duration times, which frequently lead to adverse effects.Controlled release technology aims at predictable andreproducible delivery of an active substance over an extendedperiod of time, yielding optimal response and prolongedefficiency, and thus offering considerable improvement of manytreatments. LÄS MER

  3. 22. Regional fluxes of tissue plasminogen activator in porcine endotoxemia

    Författare :Annette Nyberg; Göteborgs universitet; []
    Nyckelord :pig; endotoxin; tissue type plasminogen activator; plasminogen activator inhibitor; tumor necrosis factor ?;

    Sammanfattning : Formation of fibrin clots in the microcirculation during severe sepsis contributes to organ failure, frequently involving the lungs and the splanchnic organs. Tissue type plasminogen activator, tPA, is the key activator of intravascular fibrinolysis with plasminogen activator inhibitor type-1, PAI-1, as its main inhibitor. LÄS MER

  4. 23. G-protein - cytoskeleton interactions in the human neutrophil during chemoattracant activation

    Författare :Eva Särndahl; Eduardo Lapetina; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The human body survives constant attacks by bacteria and other pathogens thanks to the surveillance of the neutrophil leukocytcs. At the site of an infection, several messenger molecules are generated that attract neutrophils from the blood and direct their migration toward the microbes. LÄS MER

  5. 24. New insights into principles of scaffolds design for bone application

    Författare :Hongji Yan; Tim Bowden; Hong Qian; Martijn van Griensven; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chondroitin sulfate; hyaluronic acid; pH; cross-linking chemistry; bone morphogenetic protein; lithium; mesenchymal stem cell; in vivo.; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Sammanfattning : This thesis presents deeper insights into bone applicable biomaterials’ design. Poor affinity of BMP-2 towards scaffolds required supra-physiological dose administration. Though molecules containing sulfate could sustain BMP-2 release, side effects occurred due to BMP-2 supra-dose, or these sulfate-containing biomolecules. LÄS MER

  7. 25. The Horizontal Ussing Chamber Method in Studies of Nasal Drug Delivery : Method Development and Applications Using Different Formulations

    Författare :Karin Östh; Anna-Lena Ungell; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; galenisk farmaci; Pharmaceutics;

    Sammanfattning : The results from this thesis leads to the following conclusions; HUM is a useful tool that fills a gap in the in vitro methods previously available to study nasal drug delivery. Using HUM, the pig respiratory nasal mucosa can obtain acceptable viability and retain it longer than the period of time needed for a transport experiment. LÄS MER