Sökning: "bone morphogenetic protein"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden bone morphogenetic protein.

  1. 1. Craniofacial bone reconstruction with Bone Morphogenetic Protein-2

    Författare :Ann-Charlott Docherty Skogh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; bone morphogenetic protein;

    Sammanfattning : Bone defects in the craniofacial area are a clinical challenge and can be the result of trauma, tumour resection or congenital malformations. The golden standard for reconstruction is autologous bone grafts, but bone may not always be readily available and donor-site morbidity might follow. LÄS MER

  2. 2. Survival of onlay bone grafts. A study in the adult rat

    Författare :Monica Gordh; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rats; polytetrafluoroethylene; artificial; membrane; immunohistochemistry; cortical perforations; bone morphogenetic protein; bone marrow; bone; bone grafts; Odontologi; stomatology; Odontology; skull; tibia;

    Sammanfattning : The aim of this thesis was to study onlay bone grafting in the adult rat to improve graft incorporation and perservation of graft size. In 167 adult isogeneic lewis rats, the size maintenance and bone formation at the graft-host interface of uni- and bicortical onlays positioned in various environments and treatments were investigated. LÄS MER

  3. 3. The Anabolic - Anti-catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective

    Författare :Neashan Mathavan; Avdelningen för Biomedicinsk teknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bone fracture; Fracture healing; bone quality; Bone biomechanics; bone morphogenetic protein-7; Zoledronate; skeletal regeneration;

    Sammanfattning : Successful fracture repair is a complex series of coordinated processes leading to regeneration of new bone to bridge the fracture site, remodelling of the newly formed bone and restoration of skeletal function. Disruption of these processes occurs in approximately 10% of all fractures and leads to delayed or failed healing requiring surgical interventions, increased complication rates, prolonged rehabilitation and high morbidity. LÄS MER

  4. 4. Bone Regeneration with Cell-free Injectable Scaffolds

    Författare :Gry Hulsart Billström; Sune Larsson; Kenneth B Jonsson; Jöns Hilborn; Håkan Engqvist; Olle Svensson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; bone tissue engineering; hydrogel; computed tomography; positron emission tomography; large femoral bone defect; rat model; hydrogel; in vivo; osteogenesis; bone regeneration; 3R; single-photon emission computed tomography; bone morphogenetic protein 2; calcium phosphates; injectable; bisphosphonate;

    Sammanfattning : Bone is a remarkable multifunctional tissue with the ability to regenerate and remodel without generating any scar tissue. However, bone loss due to injury or diseases can be a great challenge and affect the patient significantly. Autologous bone grafting is commonly used throughout the world. LÄS MER

  5. 5. Biomaterials for Promoting Self-Healing of Bone Tissue

    Författare :Sonya Piskounova; Jöns Hilborn; Tim Bowden; Simon Cool; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; Osseointegration; implant coating; hyaluronan hydrogel; bone morphogenetic protein-2; hydroxyapatite; bone; delivery system; injectable; mixing; radioactive labeling; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : The present work addresses poor bone/implant integration and severe bone defects. In both conditions external stimuli is required for new bone to form. LÄS MER