Sökning: "sustained release"

Visar resultat 16 - 20 av 85 avhandlingar innehållade orden sustained release.

  1. 16. The effect of beta2-adrenoceptor agonists and steroids on induced airway inflammation and bronchial responsiveness

    Författare :Karin Strandberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute exposure of healthy subjects in a swine barn induces an intense airway inflammation and increased bronchial responsiveness. Dust collected in swine houses is a potent stimulus for release of pro-inflammatory cytokines from cells in vitro. LÄS MER

  3. 17. Molecular mechanisms of biphasic insulin secretion

    Författare :Nikhil R. Gandasi; Sebastian Barg; Christien Merrifield; Uppsala universitet; []
    Nyckelord :Exocytosis; Insulin secretion; Membrane trafficking; Microscopy; Diabetes; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Pancreatic beta-cells secrete insulin in response to increase in blood glucose concentration with a rapid first phase and slower, sustained second phase. This secretion pattern is similar in entire pancreas, isolated islets of Langerhans and single beta-cells and it is disrupted in type 2-diabetes. LÄS MER

  4. 18. Novel insights into the role of serotonin in control of β-cell fuction

    Författare :Hedvig Bennet; Celiaki och diabetes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Inadequate insulin secretion is a central component in the development of Diabetes Mellitus, resulting from reduced pancreatic β-cell mass, as well as diminished β-cell function. Islet produced 5-hydroxy tryptamine (5-HT) is suggested to regulate insulin secretion and β-cell mass in rodents during pregnancy and in metabolically challenged states. LÄS MER

  5. 19. The Free Fatty Acid Receptor GPR40 - expression and role in islet hormone secretion

    Författare :Erik Flodgren; Lund Medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; GPCR; Glucagon; GPR40; Insulin; Free fatty acid; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Type 2 diabetes (T2D) is a serious condition of growing proportions. Developing via an increasing imbalance between insulin sensitivity in the peripheral tissues and insulin release from pancreatic beta-cells, it ultimately renders the individual incapable of regulating the blood glucose concentration, e.g. after a meal. LÄS MER

  7. 20. On enhancement of bone formation using local drug delivery systems

    Författare :Ali Alenezi; Ann Wennerberg; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bone formation; local drug delivery systems;

    Sammanfattning : Introduction: Despite that many reports have confirmed the long-term clinical success rates associated with implant treatment, implant failure to achieve and maintain osseointegration still occurs in many cases. Local and sustained drug release at the bone-implant interface is one of the strategies that have been suggested to improve the osseointegration. LÄS MER