Sökning: "sporadic follicular thyroid tumors"

Hittade 5 avhandlingar innehållade orden sporadic follicular thyroid tumors.

1. 1. Molecular genetic studies of human thyroid tumors

   Författare :Tony Frisk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Follicular thyroid tumors; tumor progression; Cowden disease; PTEN; CGH; RET; medullary thyroid carcinoma; MEN 2; anaplastic carcinoma.;

   Sammanfattning : Tumors of the thyroid gland are common among the general population, but only a small proportion is malignant. The vast majority of thyroid tumors are benign, so called follicular adenomas. Sometimes subtypes such as atypical adenomas and adenomas with oxyphil, i.e. LÄS MER

3. 2. Basic and translational studies of follicular thyroid neoplasia

   Författare :Theodoros Foukakis; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Follicular thyroid cancer; follicular thyroid adenoma; PAX8-PPARgamma; PPARgamma; PTEN; RAS; RASSF1A; NORE1A; TERT; quantitative RT-PCR; microarray; cancer biomarker;

   Sammanfattning : Thyroid tumors occur frequently in the general population and although the majority represents benign follicular adenomas (FTA), thyroid cancer constitutes 1% of all malignancies worldwide. Among the differentiated cancers, three main types are recognized, including the papillary and follicular forms (PTC and FTC) that originate from the follicular thyrocytes, and the medullary carcinoma that arises from the C-cells. LÄS MER

4. 3. Molecular aspects of post-Chornobyl and sporadic papillary thyroid carcinoma

   Författare :Andrii Dinets; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :papillary thyroid carcinoma;

   Sammanfattning : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. LÄS MER

5. 4. Behind the scenes of thyroid tumors : underlying genetic mechanisms

   Författare :Jia Jing Lee; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Familial medullary thyroid cancer; follicular thyroid cancer; anaplastic thyroid cancer; CCND1; UBCH10; p16; RASSF1A; BRAF; array-CGH; tumor progression; global methylation; LINE-1; LUMA;

   Sammanfattning : Thyroid cancer is the most frequently observed malignancy involving endocrine tissues. This group of diseases is also the major cause of death related to neoplasia of the endocrine system. Tumors in the thyroid gland are common in the general population and the majority represents benign follicular adenoma (FTA). LÄS MER

7. 5. Approaches for the localization and identification of human cancer genes

   Författare :Wong-Onn Lui; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :CGH; FISH; SKY; karyotyping; SNP array; expression array; VHL-associated pheochromocytomas; hemangioblastomas; familial renal cell carcinoma; constitutional translocation; sporadic follicular thyroid tumors; chromosomal alterations; fusion oncogene; FTCF-PPAR gamma l; PAX8-PPAR gamma l.;

   Sammanfattning : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. LÄS MER