Sökning: "TERT"

Visar resultat 1 - 5 av 83 avhandlingar innehållade ordet TERT.

  1. 1. Clinical aspects of molecular profiles in metastatic malignant melanoma

    Författare :Henrik Ekedahl; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanom; Prognos; BRAF; TERT; Genuttryck; Next generation sequencing; Melanoma; Prognosis; BRAF; TERT; Gene Expression; Next generation sequencing;

    Sammanfattning : Malignant melanoma is a heterogeneous, malignant neoplastic disease, most often originating in the skin. Melanoma is characterized by a high mutational load and has a vastly variable prognosis, depending on disease stage. LÄS MER

  3. 2. New Insights in Adrenal Tumourigenesis

    Författare :Rajani Maharjan; Peyman Björklund; Michaela Luconi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cortisol producing adenomas; adrenocortical carcinomas; mutation; heterogeneity; PRKACA; TERT; CTNNB1; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Unilateral cortisol producing adenoma (CPA) is the most common cause of ACTH-independent Cushing’s syndrome and is surgically curable. On the other hand, adrenocortical carcinomas (ACCs) are rare and aggressive tumours. LÄS MER

  4. 3. Contact allergens in p-tert-butylphenol-formaldehyde resin

    Författare :Erik Zimerson; Yrkes- och miljödermatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dermatology; main allergens; structure-activity relationships; identification of contact allergens; guinea pig maximization test; p-tert-butylphenol-formaldehyde resin; patch testing; venereology; Dermatologi; venereologi;

    Sammanfattning : p-tert-Butylphenol-formaldehyde resin (PTBP-F-R) is used as a binder in many adhesive formulations and it consists of a complex mixture of substances, most of which are unknown. The resin has been reported to cause allergic contact dermatitis since the 1950s. LÄS MER

  5. 4. Telomerase reverse transcriptase (TERT) : promoter mutation and novel function in human cancer

    Författare :Tiantian Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, an RNAdependent DNA polymerase responsible for telomere elongation. TERT is transcriptionally repressed in most normal human somatic cells with limited life-span, which contributes to telomerase silence. LÄS MER

  7. 5. Diagnostic and prognostic markers in thyroid carcinoma with focus on TERT activation

    Författare :Ninni Mu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Well-differentiated follicular cell-derived thyroid carcinomas are usually categorized into papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC), which represent the most common and second most common types of thyroid carcinoma, respectively. PTC patients generally have a good prognosis, although a subset of patients progress in their disease with poor clinical outcome. LÄS MER