Sökning: "karyotyping"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet karyotyping.

  1. 1. Studies on the molecular pathogenesis of extraskeletal myxoid chondrosarcoma and other cartilage tumors

    Författare :Helene Sjögren; Göteborgs universitet; []
    Nyckelord :Extraskeletal myxoid chondrosarcoma; chondroblastoma; chondrosarcoma; spectral karyotyping SKY ; chromosome translocation; fusion oncogene; cDNA microarray; TEC; EWS; TAF2N; TCF12;

    Sammanfattning : .... LÄS MER

  3. 2. Mapping the genome and characterization of an acetyltransferase of Trypanosoma cruzi

    Författare :Stephen O Ochaya; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Trypanosoma cruzi; Chagas´disease; karyotyping; genomic; acetyltransferase;

    Sammanfattning : Trypanosoma cruzi (T.cruzi) is a flagellate protozoan parasite that causes Chagas' disease and is most common in Latin American countries. The disease currently infects over 13 million persons and about 100 million more are at risk. Despite basic research for many years, there is neither a vaccine nor useful drugs available to combat the disease. LÄS MER

  4. 3. Molecular studies of acute myeloid leukemia and the telomerase reverse transcriptase gene

    Författare :Charlotta Lindvall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Aacute myeloid leukaemia; telomerase hTERT; cancer cytogenetics; spectral karyotyping; gene expression profiling;

    Sammanfattning : Multiple chromosome rearrangements (MCRs) are detected in approximately 10% of patients with acute myeloid leukemia (AML), and are associated with an adverse prognosis. Comprehensive analysis of the chromosome rearrangements in these complex karyotypes has previously been hampered by the limitations of conventional cytogenetic techniques such as G-banding. LÄS MER

  5. 4. The IGF-axis in liver disease : modulation of expression by histone deacetylase inhibitors

    Författare :Steven Gray; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Liver Tumor; Histone Aceltylation; Gene expression; trichostatin A; Insulin-like growth factor axis; Comparative genomic hybridization; Spectral karyotyping;

    Sammanfattning : The Insulin-like growth factor (IGF) axis is composed of a family of ligands, receptors and binding proteins with important functions in the regulation of cell growth, apoptosis, survival, migration and development. The liver is a major provider of several of the IGF-axis members. LÄS MER

  7. 5. Approaches for the localization and identification of human cancer genes

    Författare :Wong-Onn Lui; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :CGH; FISH; SKY; karyotyping; SNP array; expression array; VHL-associated pheochromocytomas; hemangioblastomas; familial renal cell carcinoma; constitutional translocation; sporadic follicular thyroid tumors; chromosomal alterations; fusion oncogene; FTCF-PPAR gamma l; PAX8-PPAR gamma l.;

    Sammanfattning : Chromosomal aberrations have been recognized as important observations that underpin the concept of a mutator phenotype in cancer. In this thesis, two basic strategies were applied to map the location of cancer-related genes in several types of cancers. LÄS MER