Sökning: "small RNA"

Visar resultat 26 - 30 av 315 avhandlingar innehållade orden small RNA.

  1. 26. Adenoviral small non-coding RNAs : A Structural and Functional Charaterization

    Författare :Wael Kamel; Göran Akusjärvi; Ben Berkhout; Uppsala universitet; []
    Nyckelord :non-coding RNA miRNA mivaRNA canonical Dicer Ago2 TSS m7G Cap Adenovirus replication E2B;

    Sammanfattning : Since their discovery in 1953, adenoviruses have significantly contributed to the understanding of virus-host cell interactions, including mechanistic details of cellular processes such as cell cycle control and alternative RNA splicing. Among the first characterized adenoviral genes were the virus-associated RNAs (VA RNAI/II), which are produced in massive amount during a lytic infection. LÄS MER

  3. 27. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Författare :Hampus Hedlund; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Sammanfattning : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. LÄS MER

  4. 28. Structure of Small Icosahedral Viruses

    Författare :Pavel Plevka; Lars Liljas; Kaspars Tars; Michael Chapman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; biologi; med inriktning mot strukturbiologi; Biology; with specialization in structural biology;

    Sammanfattning : This thesis presents structural studies on the plant virus Ryegrass mottle virus (RGMoV), the bacteriophage φCb5, and the icosahedral particles and octahedral crystal assembly of a bacteriophage MS2 coat protein mutant. In contrast to other sobemoviruses, the RGMoV coat protein is missing several residues in two of the loop regions important for capsid assembly. LÄS MER

  5. 29. Optical Dyes for Visualization of Structure and Function of Biomolecules and Biological Membranes

    Författare :Maria Matson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Orientation; RNA; Lipid Membranes; Voltage-Sensitive Dyes; Binding Preferences; Cellular Localization; DNA; Spectroscopy; Spectral Properties; Lipophilic Ruthenium Complex;

    Sammanfattning : To visualize the structure and function of biomolecules and biological membranes in the cell, optical dyes are important tools where in particular fluorescent probes provide a sensitive and selective detection. When cellular compartments are investigated it is crucial that the probe selectively binds to the area of interest and not exhibits unspecific binding affinity. LÄS MER

  7. 30. Nanostructured surfaces created by the interactions of dendrimers and oppositely charged amphiphiles

    Författare :Marianna Yanez; Fysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PAMAM; Surfactant; SDS; Lipid; Bilayer; Model Biomembrane; Nucleolipid; DLPA; DLPU; DNA; RNA; Neutron Reflectometry; Poly amidoamine ; Interface; Adsorption; Polyelectrolyte;

    Sammanfattning : The research described in this thesis aims to understand the interactions between cationic poly(amidoamine) (PAMAM) dendrimers and small oppositely charged amphiphiles at the solid-liquid and air-liquid interfaces in relation to the bulk solution behavior. There is high interest in PAMAM dendrimers because they are well-defined polymers with a hierarchical architecture which makes them promising materials as nanocapsules and gene vectors. LÄS MER