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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Genotype-phenotype relations in SF3B1 mutated myelodysplastic syndromes with ring sideroblasts

    Författare :Simona Conte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myelodysplastic syndrome with ring sideroblasts (MDS-RS) is a clonal hematopoietic stem cell disorder characterized by hyperplastic and ineffective erythropoiesis, ring sideroblasts in the bone marrow, and anemia. Heterozygous mutations in the spliceosome gene SF3B1 are found in a majority of MDS-RS cases and are associated with the ring sideroblast phenotype and a favorable prognosis. LÄS MER

  3. 2. Ethanol from Lignocellulose - Fermentation Inhibitors, Detoxification and Genetic Engineering of Saccharomyces cerevisiae for Increased Resistance

    Författare :Simona Larsson; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; detoxification; S. cerevisiae; lignocellulose; inhibition; phenolic compounds; laccase; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Ethanol can be produced from lignocellulose by first hydrolysing the material to sugars, and then fermenting the hydrolysate with the yeast Saccharomyces cerevisiae. Hydrolysis using dilute sulphuric acid has advantages over other methods, however, compounds which inhibit fermentation are generated during this kind of hydrolysis. LÄS MER

  4. 3. Disentangling the Early History of the Solar System

    Författare :Simona Pirani; Astronomi - Genomgår omorganisation; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; planets and satellites: formation; planets and satellites: dynamical evolution and stability; Kuiper belt: general;

    Sammanfattning : Giant planets form out of a disc of gas and dust – called protoplanetary disc -- that surrounded the protosun at the time of its formation. While the cores of giant planets were growing via planetesimal and pebble accretion, they started to interact with the gas in the protoplanetary disc. LÄS MER

  5. 4. Strategies to optimize T cell-based cancer immunotherapy

    Författare :Simona Vertuani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MHC class 1; CTL; DNA vaccine; HER-2; Retinoic acid;

    Sammanfattning : Remarkable progress has been made in the field of tumor immunology in the past decade but active immunotherapy is not yet an established treatment modality. Tumor associated antigens (TAAs) presented in the form of peptides in association with MHC class 1 can be recognized by T cells and represent major targets of immunotherapy strategies to treat cancer patients. LÄS MER

  7. 5. Determinants of Health Capital at Birth: Evidence from Policy Interventions

    Författare :Simona Bejenariu; Göteborgs universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; health at birth; Romania; program evaluation; maternity leave benefits; austerity measures; fertility;

    Sammanfattning : Paper I: Austerity Measures and Infant Health. Lessons from an Unexpected Wage Cut Policy We investigate the effects on health at birth of a shock generated by a major (25%) and unexpected wage cut austerity measure that affected all public sector employees in Romania in 2010. LÄS MER