Sökning: "risk assessment RA"

Visar resultat 6 - 10 av 24 avhandlingar innehållade orden risk assessment RA.

  1. 6. Health-enhancing physical activity in rheumatoid arthritis : prevalence, intervention and assessment

    Författare :Birgitta Nordgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background and Aim: Rheumatoid arthritis (RA) is associated with poor health and functioning, and increased risk of cardiovasculardisease. Health-enhancing physical activity (HEPA), defined in the present work as “a minimum of 30 minutes of at least moderately intense daily physical activity, whereof at least twice weekly circuit training sessions including both aerobic and muscular strength training”, is a key component in the life-long management of RA as it reduces the risk of disability and comorbidity. LÄS MER

  3. 7. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment

    Författare :Nick Fletcher; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. The aims of this thesis were (1) to clarify the species and strain sensitivity of TCDDinduced retinoid disruption and (2) to identify cellular targets of TCDD-induced retinoid disruption. LÄS MER

  4. 8. Risk factors for rheumatoid arthritis : epidemiological studies of perinatal characteristics, infections and the inflammatory reflex

    Författare :Cecilia Carlens; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory disease that is characterised by symmetric polyarthritis leading to progressive joint destruction. The aim of this thesis was to contribute to better knowledge of the etiology of RA by investigating the importance of the inflammatory reflex, childhood infections and early life exposures as risk factors for RA, based on four epidemiological studies. LÄS MER

  5. 9. Health economic assessment of medical technology in chronic progressive diseases : multiple sclerosis and rheumatoid arthritis

    Författare :Gisela Kobelt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis developed a method for economic evaluation in non-fatal chronic progressive diseases, applied to multiple sclerosis (MS) and rheumatoid arthritis (RA). In economic evaluation different treatment strategies are compared in terms of their costs and their health benefits. LÄS MER

  7. 10. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability

    Författare :Lars Erik Kristensen; Reumatologi och molekylär skelettbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; response; drug survival; psoriatic arthritis; Arthritis; rheumatoid arthritis; adverse events; TNF antagonists;

    Sammanfattning : Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. LÄS MER