Sökning: "Nick Fletcher"

Hittade 1 avhandling innehållade orden Nick Fletcher.

1. 1. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment

   Författare :Nick Fletcher; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. The aims of this thesis were (1) to clarify the species and strain sensitivity of TCDDinduced retinoid disruption and (2) to identify cellular targets of TCDD-induced retinoid disruption. LÄS MER