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Visar resultat 16 - 20 av 60 avhandlingar som matchar ovanstående sökkriterier.

  1. 16. Induction of apoptosis in relation to chromatin structure and inhibition of replication by DNA damage from ionizing radiation

    Författare :Jesper Torudd; Mats Harms-Ringdahl; Mats Ljungman; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ionizing radiation; DNA-loop; replication fork; Toxicology; Toxikologi;

    Sammanfattning : The theme of this thesis has been chromatin organization ranging from methodological studies to involvement in apoptotic response. The aims have been: (i) to compare the information obtained by the AVTD method and comet assay concerning DNA-loop organization, (ii) to test the hypothesis that DNA-loop relaxation could be the triggering signal for induction of apoptosis in G0-lymphocytes, and (iii) to study the dose response for inhibition of the replication fork movement and pathways for the DNA repair process at the replication fork. LÄS MER

  3. 17. Immunological consequences of Epstein-Barr virus replication

    Författare :Andre Ortlieb Guerreiro Cacais; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus involved in the pathogenesis of a wide spectrum of malignant and non-malignant diseases. In healthy EBV carriers, the virus is believed to infect two major cellular targets - B lymphocytes and epithelial cells. LÄS MER

  4. 18. Molecular mechanisms of mammalian mitochondrial DNA replication and transcription

    Författare :Mina Pellegrini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mitochondrion; DNA polymerase gamma; mtSSB; TWINKLE; DNA replication; transcription; mTERF; MTERF3; MTERF2; nucleoid;

    Sammanfattning : Mitochondria are cytoplasmic organelles in eukaryotic cells, mainly devoted to the synthesis of ATP, through the Oxydative Phospshorylation System (OXPHOS). The organelle has its own genome, the mitochondrial DNA (mtDNA) that encodes for all the RNA components of the mitochondrial translation apparatus (two rRNAs and 22 tRNAs) and for 13 subunits of the OXPHOS complexes. LÄS MER

  5. 19. The interface of mitochondrial DNA transcription and replication

    Författare :Paulina Hannele Wanrooij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria are a dynamic network of subcellular organelles that produce the majority of cellular ATP through the process of oxidative phosphorylation (OXPHOS). The components of the respiratory chain are encoded by two separate genomes, nuclear DNA and mitochondrial DNA (mtDNA), and the proper maintenance of both of these genomic entities is therefore crucial for cellular ATP levels and the survival of the cell. LÄS MER

  7. 20. Linking transcription to DNA replication in mammalian mitochondria

    Författare :Yonghong Shi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Most of the adenosine phosphate (ATP) used to drive cellular processes is produced through oxidative phosphorylation (OXPHOS). At the heart of this process is the electron transport chain, which contains a number of protein complexes located in the inner membrane of mitochondria. LÄS MER