Sökning: "renin-angiotensin system"

Visar resultat 31 - 35 av 66 avhandlingar innehållade orden renin-angiotensin system.

  1. 31. Palladium(0)-Catalyzed Spirocyclization and Carbonylation Reactions : Ligands Targeting the Angiotensin II Type 2 Receptor

    Författare :Jens Lindman; Mats Larhed; Johan Gising; Christian Sköld; Alessandra Tolomelli; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Palladium catalysis; Mizoroki-Heck reaction; spiroindolines; spirooxindoles; amino acids; carbonylation; angiotensin II type 2 receptor; AT2R ligands; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Palladium(0)-catalyzed chemistry represents one of the most important methods for the construction of carbon-carbon bonds, which are ubiquitous in organic compounds. The first part of this thesis describes the palladium(0)-catalyzed diastereoselective Mizoroki-Heck reaction of Vince lactam-derived precursors for the formation of spiroindolines (paper I) and spirooxindoles, which are scaffolds present in several natural products with interesting biological activity. LÄS MER

  3. 32. Transcriptional activity of PPARγ in primary human adipocytes

    Författare :Lilian Sauma; Fredrik Nyström; Mats Söderström; Jan Eriksson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The prevalence of obesity is increasing in most parts of the world and is a strong risk factor for the development of insulin resistance, type 2 diabetes and hypertension. Adipose tissue is mainly composed of adipocytes which store energy in the form of triglycerides and release it as free fatty acids. LÄS MER

  4. 33. NISOLDIPINE : Clinical, biochemical, pharmacokinetic and experimental studies

    Författare :Anna-.Maria Ottosson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Nisoldipine is a new calcium channel blocker of the I ,4-dihydropyridine type. It possesses more vasoselective properties than nifedipine. LÄS MER

  5. 34. The oesophageal mucosa in reflux disease - endoscopic appearance and tissue structure

    Författare :Anders Edebo; Göteborgs universitet; []
    Nyckelord :oesophagus; reflux; angiotensin; epithelium; endoscopy;

    Sammanfattning : Gastro-oesophageal reflux disease (GORD) is very common in especially the western world. The cardinal symptoms are heartburn or regurgitations and are caused by the reflux of noxious compounds from the stomach/duodenum to the oesophagus. LÄS MER

  7. 35. Haemostatic and inflammatory alterations in hypertension and hyperlipidaemia, and the impact of angiotensin II

    Författare :Mikael Ekholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The process of atherosclerosis is multifactorial, and endothelial dysfunction is considered to precede atherosclerosis. Angiotensin (Ang) II, the main effector of renin-angiotensinaldosterone system (RAAS), is implicated in hypertension and has been shown to promote atherosclerosis. LÄS MER