Sökning: "renin-angiotensin system"

Visar resultat 21 - 25 av 66 avhandlingar innehållade orden renin-angiotensin system.

1. 21. Mesentric hemodynamics and effects of angiotensin II during circulatory stress

   Författare :Mats Laesser; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renin-angiontensin system; angiotensin II; intestines; hemodynamics; perfusion; hemorrhage; hypovolemia; endotoxemia;

   Sammanfattning : Mesenteric hypoperfusion and ischemia is considered to be deleterious to the intestinal mucosal barrier function and it is suggested that the renin-angiotensin system plays a pivotal role in the regulation of mesenteric perfusion.The present thesis examines the effects of the specific AT1 receptor blocker candesartan on mesenteric hemodynamics during acute hypovolemia and endotoxinemia. LÄS MER

3. 22. Angiotensin II and vascular disease. Studies in rats and atherosclerosis-prone mice

   Författare :Maria E Johansson; Göteborgs universitet; []
   Nyckelord :angiotensin II; atherosclerosis; AT1 receptor; AT2 receptor; blood pressure; hyperinsulinemia; hypertension; oxidative stress; salt; vascular disease; vascular function;

   Sammanfattning : Angiotensin II (Ang II) is of importance for a number of physiological processes but also plays an important pathophysiological role in cardiovascular disease. The aim of this thesis was to evaluate the role of Ang II in hypertension-related atherosclerosis and vascular disease and to investigate possible anti-atherosclerotic effects of the angiotensin II, type 2 (AT2) receptor. LÄS MER

4. 23. Angiotensin-Converting Enzyme : Effects of Smoking and Other Risk Factors for Cardiovascular Diseases

   Författare :Liza Ljungberg; Karin Persson; Rolf Andersson; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Cardiovascular diseases (CVDs) are the most common cause of death in Western countries. Smoking, hypertension, diabetes mellitus and hypercholesterolemia are considered as major risk factors. However, the underlying mechanisms by which these factors cause CVDs are not entirely clear. LÄS MER

5. 24. Bridging the gap between clinical trials and clinical practice : sacubitril-valsartan in heart failure as a model

   Författare :Helena Norberg; Krister Lindmark; Ellinor Bergdahl; Eva-Lotta Glader; Björn Wettermark; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systematic implementation; healthcare quality improvement; chronic disease management; heart failure; sacubitril-valsartan; real-world population; sex differences; kardiologi; Cardiology;

   Sammanfattning : When novel treatments prove more effective than standard therapies, a swift and effective implementation is needed to reach cost-effectiveness and to benefit eligible patients. Meanwhile, women and elderly are often under-represented in clinical trials, which creates a knowledge gap on how to optimize treatment in clinical practice. LÄS MER

7. 25. The Role of Kidney Oxygen Homeostasis for the Development of Kidney Disease

   Författare :Carla Carvalho; Fredrik Palm; Peter Hansell; Malou Friederich; Jenny Nyström; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oxygen; Kidney mitochondria; Hypoxia-inducible factors; Prolyl hydroxylase; von Hippel-Lindau; Diabetes; Aging; Kidney; Sodium; RAAS; Fysiologi; Physiology;

   Sammanfattning : The relation between oxygen supply and demand determines tissue oxygen tension (PO2). When intrarenal tissue PO2 decreases, any compensatory increase in oxygen supply via increased renal blood flow is likely to increase glomerular filtration rate. LÄS MER