Sökning: "pulmonary fibrosis"

Visar resultat 16 - 20 av 56 avhandlingar innehållade orden pulmonary fibrosis.

1. 16. Studies on neurotrophins in inflammatory pulmonary diseases

   Författare :Charlotta Dagnell; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Asthma, sarcoidosis and chronic obstructive pulmonary disease (COPD) are inflammatory pulmonary diseases, all being characterized by tissue inflammation, tissue damage (airway remodeling) and loss of lung function. In order to increase possibilities to find new biomarkers, drug targets and better treatment options for the patients, further research on the underlying mechanisms driving the inflammation and airway remodeling in these diseases are required. LÄS MER

3. 17. On dysregulated inflammation and airway host defense

   Författare :Ravi K. V. Bhongir; allergologi och palliativ medicin Lungmedicin; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aiway inflammation; Chronic obstructive pulmonary disease COPD ; Cystic Fibrosis; Pseudomonas aeruginosa; DNase I;

   Sammanfattning : Acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease (COPD), and cystic fibrosis (CF) are characterized by dysregulated inflammation of the airways. The increased influx of immune cells and the accumulation of cytokines lead to cell death, tissue destruction and impaired pulmonary function. LÄS MER

4. 18. Models of alveolar remodeling in chronic lung disease

   Författare :Oskar Rosmark; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix ECM ; Decellularization; Mass Spectrometry MS ; Biomechanics; Chronic obstructive pulmonary disease COPD ; Idiopathic pulmonary fibrosis IPF ; Alveolar epithelial cells; Fibroblasts; Lung slices;

   Sammanfattning : Lung function is highly dependent on the structure of the lung parenchyma. Remodeling of the alveolar compartment is a central part of the pathology of chronic lung disease such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). LÄS MER

5. 19. Galectin Inhibitors – Molecular Tools in Biomedical Research and Clinical Implications

   Författare :John Stegmayr; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; galectins; inhibitors; evaluation assays; cell culture; idiopathic pulmonary fibrosis; synthetic small-molecule galectin inhibitors; plant-derived polysaccharides;

   Sammanfattning : Galectins are β-galactoside-binding lectins, which are present in both the intracellular and extracellular environments of cells. During the last two decades, galectins have gained increasing interest as drug targets in various diseases, such as chronic inflammation (fibrosis) and cancer, in which galectins have been shown to play important, and sometimes rate-limiting, roles. LÄS MER

7. 20. Immunological markers and clinical characteristics of pulmonary inflammation

   Författare :Helga Haugom Olsen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Interstitial lung diseases (ILD) includes a broad spectrum of disorders affecting the lung parenchyma. Common to these conditions is the exacerbated pulmonary immunological response leading to inflammation, disordered tissue healing, and, in a proportion of patients, chronic pulmonary fibrosis. LÄS MER