Sökning: "prodrug activation"

Visar resultat 6 - 10 av 14 avhandlingar innehållade orden prodrug activation.

  1. 6. Neural stem cell-mediated enhanced gene therapy of malignant gliomas using a novel plant thymidine kinase

    Författare :Zahidul Khan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Malignant glioma; suicide gene therapy; bystander effect; gap junction; neural stem cell; 4-phenylbutyrate; epigenetics; cell differentiation;

    Sammanfattning : Malignant gliomas are the most common brain tumors in adults. Approximately, 190,000 new patients are diagnosed with malignant gliomas worldwide every year. Unfortunately, the prognosis of malignant gliomas still remains very poor, despite advances in management. LÄS MER

  3. 7. Bacteria-based methods for engineering and characterization of proteases and affinity proteins

    Författare :Lisa Sandersjöö; John Löfblom; Stefan Ståhl; Brent Iverson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bioteknologi; Biotechnology;

    Sammanfattning : This thesis is focused on the development of methods for characterization and engineering of both proteases and affinity proteins. In addition, a prodrug concept for small affinity proteins is developed.Two of the developed methods are for engineering and/or characterization of proteases. LÄS MER

  4. 8. Optimization of cyclophosphamide therapy based on pharmacogenetics

    Författare :Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

    Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER

  5. 9. Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18

    Författare :Alvin V Gomez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 superfamily represents a very important group of enzymes that are responsible for the metabolism of drugs as well as of endogenous compounds. Many P450s are genetically polymorphic causing important interindividual variability in P450 expression and activity whereas in some cases the basis for interindividual variation has still not been resolved. LÄS MER

  7. 10. Gene therapy of neuroblastoma

    Författare :Yvonne Arvidsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

    Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER