Sökning: "activation loop"

Visar resultat 1 - 5 av 127 avhandlingar innehållade orden activation loop.

1. 1. Platelet Activation and Inhibition in Connection with Vascular Stents

   Författare :Kjeld Christensen; Rolf Larsson; Sten Husted; Uppsala universitet; []
   Nyckelord :Medicine; platelets; inhibition; activation; stents; ACS; Medicin;

   Sammanfattning : This thesis describes the Chandler loop, which makes it possible to conduct studies in vitro of molecular and cellular interactions between whole blood and stents. It was possible to monitor activation and inhibition of the cascades systems, leukocytes and platelets by combining different platelet inhibitors and heparin coating of stents. LÄS MER

3. 2. Elucidating the Gating Mechanism of Cys-Loop Receptors

   Författare :Özge Yoluk; Erik Lindahl; Philip Biggin; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ion channel; gating; simulation; molecular dynamics; receptor; cys-loop; modelling; Teoretisk kemi och biologi; Theoretical Chemistry and Biology; Biological Physics; Biologisk fysik;

   Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER

4. 3. Corrosion testing of heat exchanger tubing

   Författare :Ulf Kivisäkk; KTH; []
   Nyckelord :corrosion testing; heat exchanger; stainless steels; general corrosion; immersion testing; activation; stress corrosion cracking; constant load; u-bends; relaxation; dewpoint corrosion;

   Sammanfattning : Heat exchanger tubes are commonly made from stainless steel.In a heat exchanger both the process fluid and the cooling orheating media can be corrosive. It is therefore important to beable to select materials that do not suffer from corrosion.Current methods in this area, however, suffer from limitationsand shortcomings. LÄS MER

5. 4. Understanding molecular mechanisms of protein tyrosine kinases by molecular dynamics and free energy calculations

   Författare :Yaozong Li; Kwangho Nam; Magnus Wolf-Watz; Amedeo Caflisch; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; kinase; IRK; IGF-1RK; phosphorylation; activation loop; molecular dynamics; phosphoryl transfer; alchemical free energy; dynamical network; correlation map; PCA; motion projection; Gaussian softcore; free energy landscape; kinase catalysis;

   Sammanfattning : Background: Insulin receptor kinase (IRK) and Insulin-like growth factor 1 receptor kinase (IGF-1RK) are two important members in the large class of tyrosine kinase receptors. They play pivotalroles in the regulation of glucose homeostasis, cell proliferation, differentiation, motility, andtransformation. LÄS MER

7. 5. Regulation of PDGFRβ signaling 

   Författare :Piotr Wardęga; Johan Lennartsson; Edvard Smith; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PDGF; HD-PTP; Alix; Cbl; Ub; Fer; Y857; Y771; downregulation; degradation; ubiquitination; activation loop; Cell and molecular biology; Cell- och molekylärbiologi; Medical Cell Biology; Medicinsk cellbiologi;

   Sammanfattning : Platelet-derived growth factor (PDGF) isoforms, which bind to closely related a- and b-tyrosine kinase receptors, induce migration, proliferation, survival and differentiation of mesenchymal cells. They signal by the active receptor attracting Src homology 2 (SH2) domain containing proteins, which subsequently initiate a set of signaling pathways. LÄS MER