Sökning: "plaques"

Visar resultat 6 - 10 av 310 avhandlingar innehållade ordet plaques.

  1. 6. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease

    Författare :Marie Oskarsson; Gunilla Westermark; Mikael Oliveberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; Abeta; type 2 diabetes; Alzheimer disease; BRICHOS; heparan sulfate; islet amyloid; amyloid plaques; seeding; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. LÄS MER

  3. 7. The role of smooth muscle cells in calcification of atherosclerotic plaques

    Författare :Till Seime; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Calcification (CALC) is a predominant feature of late-stage cardiovascular disease (CVD) but responsible mechanisms and its contribution to the risk of clinical events remain unclear. Formation of highly mineralized extracellular matrix (ECM) leads to progressive aortic valve stenosis (AVS) and has been identified as a surrogate marker for atherosclerotic disease burden. LÄS MER

  4. 8. Development of novel PET radioligands for visualizing beta cell mass and amyloid plaques

    Författare :Mahabuba Jahan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The aim of the thesis was twofold. The first aim was to radiolabel small molecules by using carbon-11 and fluorine-18 for visualising beta cell mass (BCM) in the pancreas by PET. Diabetes Mellitus (DM) is a chronic metabolic disorder that results from an absolute or relative lack of BCM of endocrine pancreas. LÄS MER

  5. 9. Expression profiling of human macrophages and atherosclerotic plaques to identify genes and mechanisms that modulate the development of atherosclerosis

    Författare :Daniel Hägg; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Macrophages play an important role in atherosclerosis, a disease that affects large and medium size arteries and causes clinical manifestations such as myocardial infarction or stroke. The aim of this thesis was to identify genes that are important in the development of atherosclerosis. LÄS MER

  7. 10. Studies on stable angina pectoris : risk indicators, prognosis and effects of verapamil or metoprolol treatment

    Författare :Claes Held; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :angina pectoris; haemostasis; fibrinolysis; inflammation; lipids; platelets; ultrasound; intima-media thickness; plaques; metoprolol; verapamil; prognosis; ;

    Sammanfattning : Hemostatic and fibrinolytic variables, inflammatory parameters, catecholamines and lipid parameters were studied at baseline, in a long-term prospective study of 809 patients with stable angina pectoris, and compared to results obtained in healthy control subjects (n=50). The prognostic implications of the various parameters at baseline were evaluated, as well as possible influences of drug treatment on these variables and their prognostic implications were studied. LÄS MER