Sökning: "plaques"

Visar resultat 21 - 25 av 310 avhandlingar innehållade ordet plaques.

  1. 21. Studies on vascular remodeling in acute coronary artery disease

    Författare :Fei Chen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; unstable angina; matrix metalloproteinase; apoptosis; angiogenesis; remodeling;

    Sammanfattning : Atherosclerosis is an arterial disease, characterized by endothelial dysfunction, vascular inflammation, and lipid accumulation in the vessel wall. Unstable coronary syndroms may be initiated by rupture of the atherosclerotic plaque, which may be caused by activation of matrix metalloproteinases (MMPs), apoptosis and angiogenesis. LÄS MER

  3. 22. Ultrasound Image Analysis for Automated Classification of Atherosclerotic Plaque in the Human Carotid Artery

    Författare :Peter Holdfeldt; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; classification; dynamic programming; carotid artery; Java program; image segmentation; ultrasound images; intima-media thickness; atherosclerotic plaque;

    Sammanfattning : Cardiovascular diseases, caused by atherosclerosis, is one of the most common causes of death in the industrialized world. Two risk factors, that both can be assessed with ultrasound, are the Intima-Media Thickness (IMT) in the arterial wall and the composition of the atherosclerotic plaque. LÄS MER

  4. 23. Modeling Amyloid-β Pathology in Alzheimer’s Disease Using the Arctic Mutation

    Författare :Ola Philipson; Lars Nilsson; Lars Lannfelt; Fred van Leuven; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; Amyloid; Amyloid-β; intraneuronal; transgenic mice; immunohistochemistry; ELISA; Public health medicine research areas; Folkhälsomedicinska forskningsområden; Geriatrics; Geriatrik;

    Sammanfattning : The Arctic mutation in the Amyloid-β (Aβ) domain of the Amyloid-β precursor protein (APP) causes Alzheimer’s disease (AD) and confers unique biochemical characteristics to Aβ peptides. The aims of this thesis were to evaluate a transgenic model with the Arctic mutation, and to use it to gain new insights into the mechanisms of early (pre-plaque) and late-stage Aβ pathogenesis in AD. LÄS MER

  5. 24. Innate immunity in atherosclerosis : the role of pattern recognition receptors

    Författare :Xiao-Ying Zhang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The pathogenesis of atherosclerosis is greatly influenced by the activities of both innate and adaptive immunity. Danger signals such as cholesterol crystals, oxidized LDL, and modified phospholipids may trigger sterile inflammation in atherosclerosis. LÄS MER

  7. 25. Inflammatory cytokines and NFκB in Alzheimer’s disease

    Författare :Linda Fisher; Kerstin Iverfeldt; Illana Gozes; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-amyloid; interleukin-1; interleukin-6; cell-penetrating peptide; PNA; Neurochemistry; Neurokemi;

    Sammanfattning : Alzheimer’s disease is the most common form of dementia. It is a neurodegenerative disorder characterized by extracellular senile plaques and intracellular neurofibrillary tangles. The main constituent of the senile plaques is the neurotoxic β-amyloid peptide. LÄS MER