Sökning: "plaques"

Visar resultat 11 - 15 av 310 avhandlingar innehållade ordet plaques.

  1. 11. Interactive mechanism between beta-amyloid process, alfa7 nicotinic receptor, glial cell activation and oxidative stress in Alzheimer's disease

    Författare :Wen-Feng Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Abeta; Alzheimer s disease; astrocytes; brain development; nAChRs; neuritic plaques oxidative stress; transgenic mice; knockout mice;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia with pathological features including the accumulation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs). These degenerative processes are also accompanied by impaired cholinergic transmission, oxidative stress, activated glia and inflammation reaction. LÄS MER

  3. 12. Alzheimer's disease : towards a multifaceted approach in neuropathological diagnosis

    Författare :Nenad Bogdanovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; CERAD; neurofibrillary tangles. neuritic plaques; apoE. synaptic proteins; rab3a; synaptophysin; synaptotagmin; GAP-43; neurogranin; neuronal degeneration; optical disector 1998;

    Sammanfattning : The main aim of this study has been to investigate potential neuropathological features which may play an important role in understanding the cognitive dysfunction and in making the final diagnosis of Alzheimer's disease (AD). To establish a reliable diagnosis of AD, standardisation and uniformity of the diagnostic protocols must become mandatory. LÄS MER

  4. 13. Assessing carotid plaque structure

    Författare :Isabel Goncalves; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiovascular system; Kardiovaskulära systemet; Modified LDL; Antibodies; Lipids; AP-1; Cellularity; Extracellular Matrix; Calcification; Elastin; Stroke; Gray-Scale Median; Echogenicity; Ultrasound; Atherosclerosis; Carotid Plaque;

    Sammanfattning : Atherosclerosis is the leading cause of death and disability in the western world. Its clinical complications include acute myocardial infarction, sudden death and stroke. Thirty to 40 % of all ischemic strokes are caused by a carotid stenosis. LÄS MER

  5. 14. Energy metabolism and angiogenesis in atherosclerosis and cancer

    Författare :Matias Ekstrand; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Hypoxia; Reactive oxygen species; Intussusceptive angiogenesis;

    Sammanfattning : Energy metabolism requires supply of glucose and oxygen. In atherosclerotic plaques and cancer tumors, there are local areas with mismatch in demand and supply of oxygen and nutrients. The resulting cellular energy imbalance may promote energy failure and stimulation of angiogenesis. LÄS MER

  7. 15. Ultrasonic Methods for Quantitative Carotid Plaque Characterization

    Författare :Erik Widman; Matilda Larsson; Mark L. Palmeri; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Atherosclerosis; Cardiovascular Disease; Carotid Artery; Elasticity; ex vivo; in vivo; Phantom; Plaque; Polyvinyl Alcohol; Pulse Wave Imaging; Shear Wave Elastography; Speckle Tracking; Stroke; Ultrasound; Medical Technology; Medicinsk teknologi; Atherosclerosis;

    Sammanfattning : Cardiovascular diseases are the leading causes of death worldwide and improved diagnostic methods are needed for early intervention and to select the most suitable treatment for patients. Currently, carotid artery plaque vulnerability is typically determined by visually assessing ultrasound B-mode images, which is influenced by user-subjectivity. LÄS MER