Sökning: "phosphorylated tau protein"

Visar resultat 16 - 20 av 22 avhandlingar innehållade orden phosphorylated tau protein.

  1. 16. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

    Författare :Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. LÄS MER

  3. 17. Biomarkers in preclinical familial Alzheimer disease

    Författare :Steinunn Thordardottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Alzheimer disease (AD) is a neurodegenerative disorder, characterized by the accumulation of b-amyloid (Ab) plaques and tangles consisting of hyperphosphorylated tauprotein in the brain. It accounts for 60-70% of dementia cases, making it the most common cause of dementia. LÄS MER

  4. 18. Fighting isoaspartate

    Författare :Jijing Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Isoaspartate (IsoAsp) is a damaging amino acid residue generated either from asparagine (Asn) deamidation or aspartate (Asp) isomerization. Both reactions are spontaneous in physiological conditions and require no enzymes. In isoAsp, a CH2 group is rearranged from the side chain and extends the polypeptide backbone. LÄS MER

  5. 19. Diagnosis and monitoring of sport-related concussion

    Författare :Sanna Neselius; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; mild traumatic brain injury; sport-related concussion; concussion;

    Sammanfattning : Background: Concussions are one of the most common sport-related injuries and it is known that they cause axonal and glial damage, and that there are risks for long-term effects. The aims of this thesis were to find possible methods, which may help clinicians to diagnose and monitor mild traumatic brain injury (TBI), analyse the APOEε4 allele genotype that has been associated with poor outcome after TBI and evaluate the relationship between neuropsychological assessment and brain injury biomarkers in the cerebrospinal fluid (CSF). LÄS MER

  7. 20. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Författare :Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER