Sökning: "opioid antagonist"

Visar resultat 6 - 10 av 35 avhandlingar innehållade orden opioid antagonist.

  1. 6. Imaging of the brain opioid system in amphetamine dependence

    Författare :Joar Guterstam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amphetamine dependence is a global health problem, often giving rise to severe medical and social complications in affected individuals. Unfortunately, there is still limited evidence for any specific treatment that would help amphetamine dependent patients to avoid relapse. LÄS MER

  3. 7. In vitro and postmortem studies of the brain opioid system : association to opiate dependence

    Författare :Parisa Zarnegar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Opioid system; brain; gene expression; amygdala; hippocampus; opiate dependence;

    Sammanfattning : Opioids such as heroin are highly addictive illicit drugs. The μ opioid receptor (MOR) plays a central role in mediating the effects of opiates and related opioid. LÄS MER

  4. 8. On cholecystokinin-opioid interaction in the spinal dorsal horn following peripheral nerve injury and inflammation

    Författare :Guilherme de Araújo Lucas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cholecystokinin; Cholecystokinin receptors; Morphine; Spinal cord; Axotomy; Inflammation; Peptide release; Morphine tolerance; [my]-opioid receptor; Flexor reflex; Microdialysis;

    Sammanfattning : The peptide cholecystokinin (CCK) antagonizes opioid-induced analgesia. Conversely, antagonists of CCK receptors enhance the analgesic effect of opioids. Together, these results support a role for CCK as an anti-opioid peptide in pain mechanisms. LÄS MER

  5. 9. Opioid-induced cholecystokinin release in the CNS-neurochemical mechanisms and effects of sciatic nerve lesion

    Författare :Henrik Gustafsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cholecystokinin (CCK) and opioid peptides have a similar distribution in the nervous system and CCK has been demonstrated to counteract opioid-induced analgesia at spinal and supraspinal level. An increased spinal release of CCK has been suggested to be a mechanism for the relative resistance to opioid analgesic drug in certain pain conditions following nerve lesions (i. LÄS MER

  7. 10. Central pain after spinal cord injury : experimental studies with special emphasis on pharmacological treatment

    Författare :Wei Yu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :allodynia; central pain; ischemia; spinal cord injury; intrathecal; opioid; opioid receptors; selective opioid agonists; selective opioid antagonists; tolerance; dependence; clonidine; bovine chromaffin cells; encapsulation; resiniferatoxin;

    Sammanfattning : Injuries and dysfunctions of the central nervous system can cause central pain which, according to clinical experience, is often refractory to conventional treatments. The present thesis consists of experimental studies on the mechanisms and treatments of central pain using a well-established animal model of central pain after spinal cord injury. LÄS MER