Sökning: "one-carbon metabolism"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden one-carbon metabolism.

1. 11. Systems biology of mitochondrial dysfunction

   Författare :Florian A Schober; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The human body consumes vast amounts of metabolites that are transformed into one another, modified to useful building blocks and broken down to harvest their energy. Mitochondria are at the core of this metabolic turnover and oxidative phosphorylation provides most cellular ATP in almost all human tissues. LÄS MER

3. 12. Targeting MTHFD1 and MTHFD2 as cancer treatment

   Författare :Petra Marttila; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. LÄS MER

4. 13. Exploring novel roles of metabolic enzymes MTHFD2 and PFKFB3 in cancer genome stability and their potential as anticancer therapeutic targets

   Författare :Nadilly Y Bonagas Villarreal; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Altered tumor metabolism has been described as early as the 1920s, but it was only in recent decades that proteomic and metabolomic studies revealed that the ways in which tumors rewire their nutrient and energy pathways are more diverse and have more implications for treatment outcome than previously thought. There is now a great interest in characterizing promising metabolic targets and identifying novel ways by which to exploit them for cancer treatment. LÄS MER

5. 14. Homocysteine and its determinants in relation to cardiovascular risk factors and myocardial infarction

   Författare :Elisabet Söderström; Johan Hultdin; Torbjörn K. Nilsson; Anders Larsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Homocysteine; folate; myocardial infarction; apolipoprotein; risk factors; cotinine; nicotine; tobacco; CTH; MTHFR; renal insufficiency; glomerular filtration rate; creatinine; cystatin C; shrunken pore syndrome; epidemiology; Clinical Chemistry; klinisk kemi;

   Sammanfattning : Background: Globally, cardiovascular diseases (CVD), including myocardial infarction (MI) and stroke, are the leading cause of illness and death and constitute a significant part of the disease burden in Sweden and Western Europe. Age, hypertension, smoking, obesity, dyslipoproteinemia, diabetes, and impaired renal function are considered established risk factors for CVD. LÄS MER

7. 15. Cadmium exposure and risk of kidney effects and bone fractures : population-based studies in England and Sweden

   Författare :Laura D K Thomas; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Cadmium (Cd) is a toxic metal with no beneficial biological function. The dissemination of cadmium to the surface environment, by industrial and agricultural practices, has led to increased human exposure. LÄS MER