Sökning: "nucleotide substitution"

Visar resultat 16 - 20 av 32 avhandlingar innehållade orden nucleotide substitution.

  1. 16. Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution

    Författare :Karin Wilbe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; genetic evolution; recombination; drug resistance; intrahost evolution;

    Sammanfattning : A striking characteristic of HIV is the enormous capacity of genetic variation. Frequent mutations, deletions, insertions and recombination events create a population of genetically related but non-identical viruses that is under constant change and ready to adapt to environmental changes. LÄS MER

  3. 17. The use of mass spectrometry and DNA technology in the investigation of hemoglobin disorders

    Författare :Dilip K Rai; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hemoglobin (Hb) disorders, which severely affect nearly 300,000 newborns every year, have become a global problem. The disorders manifest a wide spectrum of clinical symptoms ranging from asymptomatic to lethal conditions. LÄS MER

  4. 18. QTL Analysis in the Pig : From the Identification of Quantitative Trait Loci to the Understanding of Molecular Mechanisms

    Författare :Ellen Markljung; Leif Andersson; Göran Andersson; Göran Hjälm; Stefan Marklund; Holger Luthman; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Domestic pigs have become very different form the wild ancestors they originate from. Selection for muscle growth and meat quality has made the pig a good model for genetic studies of muscle development.The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between Landrace and Hampshire pigs. LÄS MER

  5. 19. Francisella tularensis: persistence, dissemination and source attribution : a theoretical and computational approach

    Författare :Chinmay Kumar Dwibedi; Anders Johansson; Pär Larsson; Markus Antwerpen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella; genomics; evolution; microbial forensics; dispersal; persistence; mikrobiologi; Microbiology;

    Sammanfattning : The bacterium Francisella tularensis causing tularemia in humans and other mammals displays little genetic diversity among genomes across temporal and spatial scales. F. tularensis infects humans with an extremely low infectious dose and causes natural seasonal tularemia outbreaks. LÄS MER

  7. 20. Molecular epidemiology of hepatitis A and hepatitis B virus in central America

    Författare :Patricia Arauz-Ruiz; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The genetic variability was determined for hepatitis A virus (HAV) and hepatitis B virus (HBV) strains from cases of acute and chronic hepatitis in Central America (CA). The genetic relatedness was established for the' strains to strains from other parts of the world. LÄS MER