Sökning: "Cellular reprogramming"
Visar resultat 1 - 5 av 38 avhandlingar innehållade orden Cellular reprogramming.
1. Generation of induced neurons via direct conversion in vivo and in vitro
Sammanfattning : Cellular reprogramming is when one cell is changed into another. This involves structural modifications on the DNA of a cell resulting in a transcriptional change. This occurs naturally during development when early pluripotent cells gradually differentiate into more specialized cells that finally result in a complete organism. LÄS MER
2. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells
Sammanfattning : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. LÄS MER
3. Generating Dendritic Cells by Direct Cell Reprogramming. Merging cellular reprogramming with immunology towards the development of novel cancer immunotherapies
Sammanfattning : Cell fate reprogramming towards pluripotency or alternative somatic cell-types has highlighted the plasticity of adult somatic cells, providing new technologies to generate desired cell types for tissue repair or for disease modeling. There is momentum to bring these concepts to immunology by specifying unique immune cellular identities that set in motion immune responses. LÄS MER
4. Mechanisms Underlying the Specification of Definitive Hematopoiesis
Sammanfattning : Hematopoietic stem cells (HSCs) maintain blood through self-renewal and differentiation. Although HSC transplantation is the only cure for various blood disorders, generating and maintaining HSCs in vitro remains challenging, partly due to a limited understanding of the cellular and molecular mechanisms underlying human HSC ontogeny. LÄS MER
5. Exploring Patient-Specific Cell Replacement Therapy for Parkinson's Disease
Sammanfattning : Parkinson’s disease (PD) affects over six million people worldwide and is characterised by the progressive loss of dopaminergic (DA) neurons in the substantia nigra, accumulation of pathological alpha-synuclein (αSyn), and inflammation in the brain. This leads to motor impairments including rigidity, akinesia, bradykinesia, resting tremor, and postural instability. LÄS MER