Sökning: "multivariate test"

Visar resultat 36 - 40 av 169 avhandlingar innehållade orden multivariate test.

  1. 36. Aspects of Efficient Parameter Estimation for Diesel Oxidation Catalysts

    Författare :Björn Lundberg; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MVDA; Mass Transport Modeling; Engine Test Bench; Design of Experiments; Kinetic modeling; DOC; Full Scale; Parameter Estimation; Exhaust Aftertreatment Modeling;

    Sammanfattning : In this thesis the objective was to tune the model parameters of diesel oxidation catalysts (DOC) to measurement data from engine rig experiments in an efficient manner. The scope was however not limited to the algorithm of parameter search alone but instead included the whole process starting with the design of experiments. LÄS MER

  2. 37. Directed Evolution of Glutathione Transferases with Altered Substrate Selectivity Profiles : A Laboratory Evolution Study Shedding Light on the Multidimensional Nature of Epistasis

    Författare :Wei Zhang; Bengt Mannervik; Bengt-Harald Jonsson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glutathione transferase; azathioprine; directed evolution; semi-rational design; catalytic mechanism; saturation mutagenesis; reduced amino acid alphabets; molecular docking; protein evolution; multivariate data analysis; epistasis; fitness landscape; evolutionary trajectories; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Sammanfattning : Directed evolution is generally regarded as a useful approach in protein engineering. By subjecting members of a mutant library to the power of Darwinian evolution, desired protein properties are obtained. Numerous reports have appeared in the literature showing the success of tailoring proteins for various applications by this method. LÄS MER

  3. 38. Experimental Designs at the Crossroads of Drug Discovery

    Författare :Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; Organic chemistry; Organisk kemi;

    Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER

  4. 39. Development and Test of an Imaging Instrument for Measurement of Water Droplets in Icing Conditions

    Författare :Stefani Alita Leona Rydblom; Benny Thörnberg; Aimé Lay-Ekuakille; Mittuniversitetet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Icing measurements; field study; shadowgraph imaging; edge detection; LWC; MVD.;

    Sammanfattning : Structural icing is a persistent challenge for the production of renewable energy from wind. It is mainly caused by supercooled atmospheric droplets of water, which are very common in cold climates. In the most exposed wind parks in Sweden, more than 10 per cent of annual energy production can be lost. LÄS MER

  5. 40. Measuring long-term effects of a school improvement initiative

    Författare :Joakim Svärdh; Inga-Britt Skogh; Erik Mellander; Veronica Bjurulf; Monica Rosén; KTH; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Propensity Score Analysis PSA ; effect study; quantitative evaluation; educational intervention; compulsory school; Science and Technology for All Initiative; representative sample; non-random selection; multi-level modelling; post-matching multivariate regression;

    Sammanfattning : There is a growing demand for studies applying quantitative methods to large-scale data sets for the purpose of evaluating the effects of educational reforms (UVK, 2010). In this thesis the statistical method, Propensity Score Analysis (PSA), is presented and explored in the evaluating context of an extensive educational initiative within science and technology education; the Science and Technology for All-program (NTA). LÄS MER