Sökning: "miR-21"

Visar resultat 6 - 10 av 13 avhandlingar innehållade ordet miR-21.

  1. 6. Genomic and functional analysis of microRNAs and PIWI-interacting RNAs in human cancers

    Författare :Mahmut Deniz Özata; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Small non-coding RNAs, including microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs), play an important role in gene expression regulation and are involved in many biological and pathological processes. Study of small RNA expression and function in cancer cells could contribute to greater understanding of how small RNAs are involved in cancer development. LÄS MER

  3. 7. The clinical use of genetic analyses in colorectal cancer

    Författare :Susanne Tumlin Ekelund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Colorectal cancer (CRC) is a common global disease, with a mortality rate of almost 50%. Prognosis is mainly based on the TNM classification. Surgical interventions have the potential of being curative in patients with stage I-III CRC. Adjuvant treatment with chemotherapy enhances the survival rate, especially in stage III cancer. LÄS MER

  4. 8. Potential therapies and biomarkers for LAMA2-CMD. Does the microRNA hype deliver?

    Författare :Bernardo Moreira Soares Oliveira; Muskelbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muskeldystrofi; genetic-markers; Small non-coding RNAs;

    Sammanfattning : Laminin α2 chain-deficient muscular dystrophy, or LAMA2-CMD, is a very severe disease caused by mutations in the LAMA2 gene. Skeletal muscle is the most affected tissue, with patients presenting symptoms such as hypotonia at birth, joint contractures and progressive muscle wasting. LÄS MER

  5. 9. New Biomarkers for Neuromuscular Function and Myasthenia Gravis

    Författare :Carl Johan Molin; Anna Rostedt Punga; Johan Widenfalk; Nils Hailer; Jan Verschuuren; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; myasthenia gravis; neuromuscular function; neurophysiology;

    Sammanfattning : Myasthenia gravis (MG) is an autoimmune disorder, which is caused by autoantibodies against the acetylcholine receptor (AChR). The cardinal symptom is muscle fatigue, which can range from slight weakness of the extraocular muscles (causing droopy eyelids or double vision), to paralysis of the respiratory muscles. LÄS MER

  7. 10. Axl RTK and microRNAs in urogenital cancers

    Författare :Helena Fritz; Malmö Klinisk kemi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : This thesis is based on four projects focused on the Axl receptor tyrosine kinase (RTK) and microRNAs in clear cell renal cell carcinoma (ccRCC) and in prostate cancer (PCa). Paper I focuses on differentially expressed microRNAs in ccRCC. LÄS MER