Sökning: "knockout mouse"
Visar resultat 6 - 10 av 198 avhandlingar innehållade orden knockout mouse.
6. Fc receptors and feedback enhancement of antibody responses
Sammanfattning : Antibodies are important for the defence against microorganisms, but are also involved inpathological reactions such as allergy or autoimmunity. The exact mechanisms involved inregulation of antibody responses is still largely unknown. In this thesis, immune regulationby antibodies and the receptors they bind to (FcR), were investigated. LÄS MER
7. Non-invasive ultrasound-based cardiovascular imaging in mouse models of atherosclerosis
Sammanfattning : Atherosclerosis is a chronic multi-factorial vascular disease. It generally requires large clinical settings and over many years to study the disease progression in man. Genetically modified mouse models of atherosclerosis have dramatically increased research feasibility within this area. LÄS MER
8. Investigating the function of Anaplastic Lymphoma Kinase
Sammanfattning : Anaplastic Lymphoma Kinase (ALK) was discovered in 1994, as a chromosomal translocation, t(2;5)(p23;q35), often seen in Anaplastic Large Cell Lymphomas (ALCL). Since then ALK has been extensively studied in this disease as well as in different model organisms. LÄS MER
9. The Role of Hox Transcription Factors in the Regulation of Hematopoiesis
Sammanfattning : Hematopoiesis is a lifelong, dynamic process, originating from a low number of hematopoietic stem cells (HSCs) residing in the adult bone marrow with the ability to self-renew and generate all blood lineages throughout life. Recent findings have demonstrated that the Homeobox (Hox) transcription factors are important regulators of both normal and malignant hematopoiesis, controlling proliferation, differentiation and self-renewal of hematopoietic cells at different levels of the hematopoietic hierarchy. LÄS MER
10. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
Sammanfattning : Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role, not only due to their central function in metabolism, but also because many proteins with apoptosisrelated functions are located in the mitochondrion. LÄS MER