Sökning: "issaeva"
Hittade 3 avhandlingar innehållade ordet issaeva.
1. Selective induction of apoptosis in tumors by small molecules reactivating p53
Sammanfattning : Lesions in the p53 pathway that inactivate p53 tumor suppression function occur with extremely high frequency in cancer, targeting almost all tumors regardless of patient age or tumor type. This study is aimed at developing approaches for the selective elimination of tumors carrying defects in the p53 pathway, namely protection of p53 from degradation by its own destructor HDM2 in wild type p53-carrying tumors and refolding of p53 by small molecules in mutant p53-containing tumors. LÄS MER
2. Interplay between Transcription and Homologous Recombination in the Presence of DNA Damage
Sammanfattning : The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. LÄS MER
3. p53 reactivation by the small molecule RITA : molecular mechanisms
Sammanfattning : Inactivation of the tumor suppressor p53 is essential for the development and maintenance of cancer cells. Therefore, reactivation of p53 appears to be a promising strategy for anti-cancer therapy. LÄS MER