Sökning: "6-thioguanine"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet 6-thioguanine.

  1. 1. Human lymphocytes in mutation assays : flow cytometric studies of 6-thioguanine resistant cells

    Författare :Leif Eriksson; Uppsala universitet; []

    Sammanfattning : .... LÄS MER

  2. 2. Interplay between Transcription and Homologous Recombination in the Presence of DNA Damage

    Författare :Ivaylo Stoimenov; Thomas Helleday; Niklas Schultz; Natalia Issaeva; Thierry Nouspikel; Stockholms universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; homologous recombination; transcription; DRB; UVC; 6-thioguanine; mammalian cells; BRCA1; BRCA2; PARP inhibitors; XP-V; Molecular biology; Molekylärbiologi; molekylärgenetik; Molecular Genetics;

    Sammanfattning : The biochemical processes of DNA repair, replication and recombination compete for the same substrate, the DNA molecule. This competition is natural, as each process requires the same template. In order to resolve possible conflicts between these processes, when they take place on a particular stretch of DNA, certain crosstalk is expected. LÄS MER

  3. 3. Pharmacological and molecular investigations on the mechanisms underlying resistance of human leukaemia cells to the antimetabolites methotrexate, 6-mercaptopurine and 6-thioguanine

    Författare :Alan Kambiz Fotoohi; Karolinska Institutet; Karolinska Institutet; []

    Sammanfattning : The goal of this thesis has been to elucidate the mechanisms underlying resistance to methotrexate (MTX), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG), the antimetabolites widely used in treatment of childhood leukemia, as well as to determine the influence of 7-hydroxymethotrexate (7-OHMTX), the major metabolite of MTX, on the therapeutic action of MTX. Resistant sublines of leukemic cell lines were developed by long-term exposure to stepwise increasing concentrations of these different agents. LÄS MER

  4. 4. Optimizing Chemotherapy in Childhood Acute Myeloid Leukemia

    Författare :Josefine Palle; Gudmar Lönnerholm; Britt-Marie Frost; Rolf Larsson; Henrik Schröder; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; childhood; acute myeloid leukemia; drug resistance; pharmacokinetics; chromosomal abnormalities; Down syndrome; MLL-rearrangement; t 9; 11 ; Paediatric medicine; Pediatrisk medicin;

    Sammanfattning : Despite major advances in our understanding of the biology of childhood acute myeloid leukemia (AML) and the development of new cytotoxic drugs, the prognosis of long-term survival is still only 60-65 %.In the present research, we studied the pharmacokinetics of drugs used in the induction therapy of childhood AML and performed in vitro drug sensitivity testing of leukemic cells from children with AML. LÄS MER

  5. 5. Development of new methodology for therapeutic drug monitoring of thiopurine treatment

    Författare :Svante Vikingsson; Curt Peterson; Björn Carlsson; Martin Josefsson; Sven Almer; Johan Ahlner; Lynne Lennard; Linköpings universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Thiopurines; mercaptopurine; thioguanine; azathioprine; crohn s disease; ulcertive colitis; HPLC; TGN;

    Sammanfattning : The three thiopurine drugs azathioprine (AZA), 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) are used to treat several diseases, including inflammatory bowel disease (IBD). They are pro-drugs and are believed to act through the formation of thioguanine nucleotides (TGNs). LÄS MER