Sökning: "in vitro evolution"

Visar resultat 31 - 35 av 100 avhandlingar innehållade orden in vitro evolution.

  1. 31. Search for genetic determinants of Plasmodium falciparum malaria drug resistance in vitro and in vivo

    Författare :Aminatou Kone; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Malaria remains the most deadly disease in the world with nearly 627 000 deaths and more than 200 million new clinical cases every year, the large majority occurring in sub Saharan Africa children aged < 5 years. This represents anyway a significant decrease as compared with the situation in the start of the Millennium. LÄS MER

  3. 32. Evolutionary Mechanisms Shaping Bacterial Translation Termination

    Författare :Shreya Pundir; Suparna Sanyal; Martin Ott; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Ribosome; Protein; Release Factor; Translation; Termination; Stop codon; Evolution; Mutation; Kinetics; Cryo-EM; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Translation termination in bacteria involves precise reading of stop codons (UAA, UAG, UGA) and coordinated peptidyl-tRNA hydrolysis by the class-I release factors (RFs) on the ribosome (70S). This thesis investigates the evolutionary and post-translational modification mechanisms of these RFs and the concurrent effect on bacterial translation termination. LÄS MER

  4. 33. Immunodominant proteins in Giardia lamblia

    Författare :Malin Weiland; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The protozoan parasite Giardia lamblia is a major cause of diarrhoea in humans and other mammals. Infection starts by ingestion of infectious cysts that excyst in the upper part of the small intestine and attach to intestinal epithelial cells. LÄS MER

  5. 34. Regulation of Lipoprotein Lipase Activity : an In-vitro Study of a Complex and Dynamic System

    Författare :Oleg Kovrov; Gunilla Olivecrona; Aivar Lookene; Mikael Larsson; Geesje Dallinga-Thie; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Triglyceride Metabolism; Lipoprotein lipase; Angiopoietin-Like Proteins; Apolipoproteins; Isothermal titration calorimetry; Biochemistry; biokemi; molekylärbiologi; Molecular Biology;

    Sammanfattning : The progress of human society outpaces our biological evolution, and this brings unexpected health problems. The industrial revolution brought up dramatic changes in nutrition and lifestyle – we are increasingly shifting towards a nutrient-rich Western-patterned diet and to a sedentary lifestyle. LÄS MER

  7. 35. Microenvironmental Impact on Tumour Cell Phenotype and Genotype in Adult and Paediatric Tumours

    Författare :Hiroaki Yasui; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genotype; cancer phenotype; malignant rhabdoid tumour; neuroblastoma; ovarian cancer; tumour evolution; Wilms tumour;

    Sammanfattning : This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. LÄS MER