Sökning: "heterologous expression"

Visar resultat 31 - 35 av 99 avhandlingar innehållade orden heterologous expression.

  1. 31. Expansion of circulatory Vγ9Vδ2 T cells in tularemia and Pontiac fever, two intracellular bacterial diseases with widely different clinical expression

    Författare :Michal Kroca; Dieter Kabelitz; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Francisella tularensis; Gamma-delta T cell; Legionella; Legionellosis; Lymphocyte; T cell Tularemia; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Although well established that human Vγ9Vδ2 T cells may expand in circulation during intracellular bacterial infections, most underlying studies included only a few cases and only some diseases had been studied so far. In tularemia, a severe invasive disease, only one patient had been described. LÄS MER

  3. 32. Development of a recombinant protein vaccine against Plasmodium falciparum malaria

    Författare :Sanjay Ahuja; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Vaccine; Plasmodium falciparum; DBL1alpha ; cross-reactivity; E.coli; recombinant expression; soluble protein;

    Sammanfattning : Malaria, caused by Plasmodium falciparum is one of the world´s deadliest diseases, killing one to two million children, while another 500 million suffer from clinical attacks every year. Infections caused by P. LÄS MER

  4. 33. Alphavirus vectors as recombinant vaccines

    Författare :Peter Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Semliki Forest virus; Alphavirus; Synthetic vaccmes; Influenza A virus; HIV-I; SIV; DNA vaccines; AIDS vaccines; Influenza vaccine;

    Sammanfattning : This thesis describes further developments of an expression system based on the alphavirus Semliki Forest virus (SFV), and its potential use as recombinant vaccine. The RNA genome of SFV contains a 3'open reading frame (ORF) encoding the structural proteins, and a 5' ORF coding for the viral replicase. LÄS MER

  5. 34. Yeasts as cellular factories: Saccharomyces cerevisiae strains with improved inhibitor-tolerance to furaldehydes via a mutant alcohol dehydrogenase- and- Human ameloblastin production in Pichia pastoris

    Författare :Boaz Laadan; Teknisk mikrobiologi; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : Several yeast species, usually engineered by humans in order to produce compounds of biotechnological interests, are currently used as cellular factories. This thesis presents two main themes. LÄS MER

  7. 35. Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes

    Författare :Anna Westlind Johnsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order to be excreted. LÄS MER