Sökning: "glucagon-like peptide 1"
Visar resultat 1 - 5 av 51 avhandlingar innehållade orden glucagon-like peptide 1.
1. Central actions of glucagon-like peptide-1 on food intake and reward: Novel neurological targets and sex divergent effects
Sammanfattning : Obesity is one of the biggest health risks of our society; however, treatment options are sparse and often result in suboptimal weight-loss. The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist liraglutide was recently approved for treatment of obesity in the US. LÄS MER
2. Glucagon-like peptide-1 and alcohol-mediated behaviors in rodents
Sammanfattning : Alcohol use disorder (AUD) is a serious cause of morbidity and mortality. However, due to the limited efficacy of existing pharmacotherapies, further investigations of potential neurochemical targets are required to define new pharmacological interventions. LÄS MER
3. The endocrine heart - metabolic actions of atrial natriuretic peptide
Sammanfattning : Abstract The natriuretic peptides (NPs), namely atrial natriuretic peptide (ANP) and bran natriuretic peptide (BNP), which are secreted from cardiomyocytes in response to cardiac wall stress, play a significant role in the regulation of blood pressure, intravascular volume, and cardiac remodeling. Recently, NPs emerged as hormones with metabolic actions such as inhibition of the renin-angiotensin system and inhibition of inflammation, together with lipolysis and adipose tissue browning. LÄS MER
4. Gastric Bypass in Morbid Obesity : Postoperative Changes in Metabolic, Inflammatory and Gut Regulatory Peptides
Sammanfattning : This thesis examines the effect of surgical weight loss on gut and adipose tissue peptides involved in appetite regulation and energy homeostasis in morbidly obese humans. Roux-en-Y gastric bypass (RYGBP) is the gold standard operation used for effective long-term weight loss and improved health. LÄS MER
5. Appetite-regulating peptides and natural rewards: emphasis on ghrelin and glucagon-like peptide-1
Sammanfattning : Evolutionary conserved natural behaviors, such as foraging and sexual behaviors, are strongly associated with reward processes. Brain areas important for reward processes include, but are not limited to, the nucleus accumbens (NAc) shell, the ventral tegmental area (VTA), the laterodorsal tegmental area (LDTg) and the nucleus of the solitary tract (NTS). LÄS MER