Sökning: "genome wide scan"

Visar resultat 16 - 20 av 34 avhandlingar innehållade orden genome wide scan.

  1. 16. QTL Analysis in the Pig : From the Identification of Quantitative Trait Loci to the Understanding of Molecular Mechanisms

    Författare :Ellen Markljung; Leif Andersson; Göran Andersson; Göran Hjälm; Stefan Marklund; Holger Luthman; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Domestic pigs have become very different form the wild ancestors they originate from. Selection for muscle growth and meat quality has made the pig a good model for genetic studies of muscle development.The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between Landrace and Hampshire pigs. LÄS MER

  3. 17. Molecular genetics of type 2 diabetes

    Författare :Li Luosheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Type 2 diabetes; the Goto-Kakizaki rat; linkage analysis; quantitative trait locus; gene-gene interaction; high fat diet; disease progression; alternative splicing; comparative genomics.;

    Sammanfattning : Type 2 diabetes is a common and chronic disease caused by interactions between genetic and environmental factors. The Goto-Kakizaki (GK) rat is a well-established genetic model of type 2 diabetes. LÄS MER

  4. 18. Search for MODY and Type 2 diabetes genes

    Författare :Markku Lehto; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2 diabetes; mutation; MODY; mitochondrial DNA; MIDD; insulin deficiency; hepatocyte nuclear factor; Gestational diabetes; glucokinase; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Diabetes is a heterogeneous disease influenced by both environmental and genetic factors. Maturity-onset diabetes of the young (MODY) is considered as a subform of Type 2 diabetes, which is inherited in an autosomal dominant fashion and expressed at childhood or early adult life. LÄS MER

  5. 19. Hypospadias : gene mapping and candidate gene studied

    Författare :Thi Thai Hanh Trinh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Hypospadias is a common congenital malformation in boys, characterized by incomplete fusion of the urethral folds, abnormal opening of urethra and different degrees of curvature of the penis. In Sweden, the incidence of hypospadias is 1.14 per 300 male live-births according to the annual Swedish Malformation Registry. LÄS MER

  7. 20. Genetic studies of susceptibility to diabetes mellitus with emphasis on type 1 diabetes

    Författare :Pernilla Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes mellitus is a common multifactorial disease that needs lifelong treatment of insulin and/or oral treatment to prevent hyperglycaemia. Despite treatment, patients with diabetes, still suffer from severe complications later in life. LÄS MER