Sökning: "fetal liver cells"

Visar resultat 11 - 15 av 48 avhandlingar innehållade orden fetal liver cells.

  1. 11. Molecular and cellular analysis of Lhx2 function in hematopoietic stem cells

    Författare :Karin Richter; Leif Carlsson; Andrew Elefanty; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Hematopoietic stem cells; Lhx2; cell lines; self renewal; SCF; IL-6; chronic myeloproliferative disorder; global gene expression analysis; Molecular biology; Molekylärbiologi;

    Sammanfattning : The formation of blood, hematopoiesis, is a dynamic process originating from a small number of hematopoietic stem cells (HSCs). To sustain hematopoiesis throughout life HSCs have the unique capacity to differentiate into all mature hematopoietic lineages as well as generating more HSCs by a mechanism referred to as self-renewal. LÄS MER

  3. 12. Methylome and Transcriptome Profiling of Hepatocytes Derived from Human Pluripotent Stem Cells

    Författare :Nidal Ghosheh; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human pluripotent stem cells; gene transcription; gene regulation; DNA methylation; transcriptome; hepatocytes;

    Sammanfattning : Six hundred million people suffering from liver diseases worldwide of which the lethality is two million. Freshly isolated hepatocytes from the liver have been used for transplantation purposes and are extensively used to recapitulate drug metabolism. LÄS MER

  4. 13. Role of MAIT cells in human antimicrobial immunity

    Författare :Joana Dias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mucosa-associated invariant T (MAIT) cells are a relatively recently discovered subset of unconventional T cells. In humans, MAIT cells are predominantly CD8+CD4- (CD8+) with a smaller CD8-CD4- (double-negative, DN) subset, and they are abundant in the peripheral blood, liver, and mucosal tissues. LÄS MER

  5. 14. Modelling and genetic correction of liver genetic diseases

    Författare :Mihaela Zabulica; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The urea cycle is a set of biochemical reactions that converts highly toxic ammonia into urea for excretion. Deficiencies in any of the genes of the cycle can be life-threatening, with liver transplantation currently being the only definitive treatment. LÄS MER

  7. 15. The ontogeny and regulation of human natural killer cells

    Författare :Martin A Ivarsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural Killer (NK) cells are members of the innate lymphoid cell (ILC) family and take part in the detection and eradication of virus-infected and transformed cells. In this thesis, together with my colleagues I have investigated how NK cells and other ILCs develop and function during human fetal development, how NK cells are functionally regulated (educated) via the activating receptor KIR2DS1, and how NK cells in our body are affected during the early phase of an acute viral infection. LÄS MER