Sökning: "evaluation in vitro toxicity"

Visar resultat 6 - 10 av 29 avhandlingar innehållade orden evaluation in vitro toxicity.

1. 6. Evaluation of neurotoxic properties of gliotoxin

   Författare :Viktoria Axelsson; Anna Forsby; Marion Ehrich; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mycotoxin; gliotoxin; A. fumigatus; cytotoxicity; neurotoxicity; Neurochemistry; Neurokemi;

   Sammanfattning : The occurrence of mould in food and animal feed is a severe problem due to the secondary metabolites, called mycotoxins, which can possess toxic activity. Aspergillus fumigatus is a common fungus found in improperly stored animal feed and the abundance of spores of the fungus is frequently spread into the air. LÄS MER

3. 7. Evaluation of Functionalized Biopolymers as a Step Toward Targeted Therapy of Osteoporosis

   Författare :Sujit Kootala; Jöns Hilborn; Peter Thomsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Osteoporosis; Bone regeneration; Biomaterials; Hyaluronic acid; Bisphosphonates; Osteoclasts; Osteoblasts; Growth factors; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

   Sammanfattning : The work presented in this thesis focuses on the development of strategies and smart bioactive materials for the treatment of osteoporosis. High and low molecular weight soluble hyaluronic acid-bisphosphonate (HA-BP) derivatives were investigated for their ability to inhibit osteoclasts. LÄS MER

4. 8. Identification and evaluation of growth hormone antagonists

   Författare :Linda Rosengren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : States in which Growth hormone (GH) levels are elevated have been implicated in several physiological disorders such as acromegaly, diabetic complications and progression of malignancies. Classical treatments for acromegaly are surgery and radiotherapy but also pharmacological therapies exist. LÄS MER

5. 9. Cell-penetrating peptides in model membrane systems : Interaction, structure induction and membrane effects

   Författare :Mazin Magzoub; Astrid Gräslund; Steven Dowdy; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik;

   Sammanfattning : Despite continuing advances in the development of macromolecules, including peptides, proteins, and oligonucleotides, for therapeutic purposes, the successful application of these hydrophilic molecules has so far been hampered by their inability to efficiently traverse the plasma membrane. The discovery of a class of peptides (cell-penetrating peptides, CPPs) with the ability to mediate the non-invasive and efficient import of a whole host of cargoes, both in vitro and in vivo, has provided a new means by which the problem associated with cellular delivery can be circumvented. LÄS MER

7. 10. Challenges in the management of urothelial cancer : novel treatment, evaluation of biomarkers, and imaging techniques

   Författare :Carl-Henrik Shah; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Urothelial cancer (UC) is the most common malignancy found in the urinary tract. The global annual incidence is approximately 430 000 new cases (Sweden: 3 200 new cases). Approximately one in four new UC patients being diagnosed has muscle-invasive disease. LÄS MER