Sökning: "cyclooxygenase COX"

Visar resultat 21 - 25 av 74 avhandlingar innehållade orden cyclooxygenase COX.

  1. 21. Prevention of Postoperative Duodenal Ileus by COX-2 Inhibition Improves Duodenal Function in Anaesthetised Rats

    Författare :John Sedin; Olof Nylander; Markus Sjöblom; Lars Fändriks; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; duodenum; motility; enteric nervous system; luminal alkalinisation; CFTR; VIP; luminal Cl-; fluid secretion; solute absorption; mucosal permeability; 51Cr-EDTA; luminal osmolality; luminal hypertonicity; glucose; mannitol; orange juice; parecoxib; hexamethonium; mecamylamine; Physiology; Fysiologi;

    Sammanfattning : Abdominal surgery inhibits gastrointestinal motility, a phenomenon referred to as postoperative ileus. Since the postoperative ileus disturbs duodenal physiology it is important to minimize the side effects of this condition. LÄS MER

  3. 22. Studies on expression and regulation of phospholipase A2 and cyclooxygenase 2 in gastrointestinal tissues with special reference to colorectal cancer

    Författare :Jan Dimberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The phospholipases A2 (PLA2s) are phospholipid hydrolyzing enzymes that in mammalian cells exist in several different isoform including cytosolic PLA2 (cPLA2), group I PLA2 (PLA2-I) and group II PLA2 (PLA2-ll). PLA2 is involved in production of inflammatory mediators, membrane remodelling, digestive functions and stimulation of prolifemtion. LÄS MER

  4. 23. Prostanoids and colorectal cancer

    Författare :Annika Gustafsson Asting; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer prostanoid receptors cyclooxygenase PGE2 transcription factors;

    Sammanfattning : Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. LÄS MER

  5. 24. An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids

    Författare :Ewa Selg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leukotrienes; prostaglandins; histamine; guinea pig lung; ovalbumin; mast cell; cyclooxygenase; airway smooth muscle; COX inhibitors; NSAIDs;

    Sammanfattning : Mast cells have a central role in the inflammatory response in airways of both atopic and non-atopic asthmatics. The mast cell-derived mediators such as histamine, leukotriene C4 and prostaglandin D2, released upon activation of the cell, produce acute bronchoconstriction that is characteristic of the early asthmatic response (EAR), and contribute to the development of airway inflammation and hyperresponsiveness following the initial reaction. LÄS MER

  7. 25. Endometrial receptivity and development of new contraceptive methods

    Författare :Lena Marions; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mifepristone; levonorgestrel; endometrial receptivity; emergency contraception; blastocyst implantation; integrins; cyclooxygenase;

    Sammanfattning : Ovulation and endometrial development as well as contraceptive efficacy was studied after treatment with the antiprogestin mifepristone. Mechanism of action after treatment with the gestagen levonorgestrel or mifepristone in doses effective for emergency contraception was also evaluated. LÄS MER